Kaposi's Sarcoma-Associated Herpesvirus Latent Gene vFLIP Inhibits Viral Lytic Replication through NF-kappaB-Mediated Suppression of the AP-1 Pathway: A Novel Mechanism of Virus Control of Latency. Export

@article{citeulike:2463408, abstract = {Kaposi's sarcoma-associated herpesvirus (KSHV) latency is central to the evasion of host immune surveillances and induction of KSHV-related malignancies. The mechanism of KSHV latency remains unclear. Here, we show that KSHV latent gene vFLIP promotes viral latency by inhibiting viral lytic replication. vFLIP suppresses the AP-1 pathway, which is essential for KSHV lytic replication, by activating the NF-kappaB pathway. Thus, by manipulating two convergent cellular pathways, vFLIP regulates both cell survival and KSHV lytic replication to promote viral latency. These results also indicate that the effect of NF-kappaB pathway on KSHV replication is determined by the status of the AP-1 pathway, and hence provide a mechanistic explanation for the contradictory role of the NF-kappaB pathway in KSHV replication. Since the NF-kappaB pathway is commonly activated during infection of gammaherpesviruses, these findings might have general implications for the control of gammaherpesviral latency.}, address = {Tumor Virology Program, Greehey Children's Cancer Research Institute; Departments of Pediatrics, Microbiology and Immunology, Molecular Medicine and Medicine; and Cancer Treatment and Research Center, The University of Texas Health Science Center, San Antonio, TX, USA; and Tumor Virology Group, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.}, author = {Ye, Feng-Chun C. and Zhou, Fu-Chun C. and Xie, Jian-Ping P. and Kang, Tao and Greene, Whitney and Kuhne, Kurt and Lei, Xiu-Fen F. and Li, Qui-Hua H. and Gao, Shou-Jiang J.}, citeulike-article-id = {2463408}, citeulike-linkout-0 = {http://dx.doi.org/10.1128/JVI.02370-07}, citeulike-linkout-1 = {http://jvi.asm.org/cgi/content/abstract/82/9/4235}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18305042}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18305042}, day = {27}, doi = {10.1128/JVI.02370-07}, issn = {1098-5514}, journal = {J Virol}, keywords = {kshv, vflip}, month = {February}, posted-at = {2008-03-04 22:02:44}, priority = {0}, title = {Kaposi's Sarcoma-Associated Herpesvirus Latent Gene vFLIP Inhibits Viral Lytic Replication through NF-{kappa}B-Mediated Suppression of the AP-1 Pathway: A Novel Mechanism of Virus Control of Latency.}, url = {http://dx.doi.org/10.1128/JVI.02370-07}, year = {2008} }

TY - JOUR ID - citeulike:2463408 L3 - citeulike-article-id:2463408 N2 - Kaposi's sarcoma-associated herpesvirus (KSHV) latency is central to the evasion of host immune surveillances and induction of KSHV-related malignancies. The mechanism of KSHV latency remains unclear. Here, we show that KSHV latent gene vFLIP promotes viral latency by inhibiting viral lytic replication. vFLIP suppresses the AP-1 pathway, which is essential for KSHV lytic replication, by activating the NF-kappaB pathway. Thus, by manipulating two convergent cellular pathways, vFLIP regulates both cell survival and KSHV lytic replication to promote viral latency. These results also indicate that the effect of NF-kappaB pathway on KSHV replication is determined by the status of the AP-1 pathway, and hence provide a mechanistic explanation for the contradictory role of the NF-kappaB pathway in KSHV replication. Since the NF-kappaB pathway is commonly activated during infection of gammaherpesviruses, these findings might have general implications for the control of gammaherpesviral latency. JF - J Virol SN - 1098-5514 AD - Tumor Virology Program, Greehey Children's Cancer Research Institute; Departments of Pediatrics, Microbiology and Immunology, Molecular Medicine and Medicine; and Cancer Treatment and Research Center, The University of Texas Health Science Center, San Antonio, TX, USA; and Tumor Virology Group, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. TI - Kaposi's Sarcoma-Associated Herpesvirus Latent Gene vFLIP Inhibits Viral Lytic Replication through NF-{kappa}B-Mediated Suppression of the AP-1 Pathway: A Novel Mechanism of Virus Control of Latency. KW - kshv KW - vflip AU - Ye, Feng-Chun AU - Zhou, Fu-Chun AU - Xie, Jian-Ping AU - Kang, Tao AU - Greene, Whitney AU - Kuhne, Kurt AU - Lei, Xiu-Fen AU - Li, Qui-Hua AU - Gao, Shou-Jiang PY - 2008/02/27/ UR - http://dx.doi.org/10.1128/JVI.02370-07 ER -