The murine gammaherpesvirus-68 M11 protein inhibits Fas- and TNF-induced apoptosis. Export

@article{citeulike:2573344, abstract = {The murine gammaherpesvirus-68 (MHV-68) M11 gene encodes a protein predicted to have limited homology to the bcl-2 family of proteins. Unlike most of the other viral bcl-2 homologues, which have both BH1 and BH2 domains conserved with respect to bcl-2, the M11 protein has a BH1 domain, but apparently lacks a BH2 domain. Transfection of HeLa cells with an epitope-tagged MHV-68 M11 construct showed that the protein is predominantly located in the cytoplasm of cells. In HeLa cells, M11 inhibited apoptosis induced by anti-Fas antibody and by TNF-alpha. Thus, despite its limited conservation with respect to other bcl-2 family members, the MHV-68 M11 protein is a potent inhibitor of apoptosis.}, address = {Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.}, author = {Wang, G. H. and Garvey, T. L. and Cohen, J. I.}, citeulike-article-id = {2573344}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10573168}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10573168}, comment = {no mechanism suggested for apoptotic resistance}, issn = {0022-1317}, journal = {J Gen Virol}, keywords = {apoptosis, mhv68}, month = {October}, pages = {2737--2740}, posted-at = {2008-03-22 23:49:02}, priority = {5}, title = {The murine gammaherpesvirus-68 M11 protein inhibits Fas- and TNF-induced apoptosis.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10573168}, volume = {80 ( Pt 10)}, year = {1999} }

TY - JOUR ID - citeulike:2573344 L3 - citeulike-article-id:2573344 N2 - The murine gammaherpesvirus-68 (MHV-68) M11 gene encodes a protein predicted to have limited homology to the bcl-2 family of proteins. Unlike most of the other viral bcl-2 homologues, which have both BH1 and BH2 domains conserved with respect to bcl-2, the M11 protein has a BH1 domain, but apparently lacks a BH2 domain. Transfection of HeLa cells with an epitope-tagged MHV-68 M11 construct showed that the protein is predominantly located in the cytoplasm of cells. In HeLa cells, M11 inhibited apoptosis induced by anti-Fas antibody and by TNF-alpha. Thus, despite its limited conservation with respect to other bcl-2 family members, the MHV-68 M11 protein is a potent inhibitor of apoptosis. JF - J Gen Virol SN - 0022-1317 AD - Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. EP - 2740 TI - The murine gammaherpesvirus-68 M11 protein inhibits Fas- and TNF-induced apoptosis. VL - 80 ( Pt 10) SP - 2737 KW - apoptosis KW - mhv68 N1 - no mechanism suggested for apoptotic resistance AU - Wang, GH AU - Garvey, TL AU - Cohen, JI PY - 1999/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/10573168 ER -