Changing patterns of dominance in the CD8+ T cell response during acute and persistent murine gamma-herpesvirus infection. Export

@article{citeulike:2651467, abstract = {The murine gamma-herpesvirus MHV-68 causes an acute, transient pneumonitis, followed by an infectious mononucleosis (IM)-like illness with splenomegaly, widespread latent infection of B lymphocytes and an expansion of Vbeta4+ CD8+ T cells. CD8+ T cells specific for an H-2Db-restricted epitope were prominent during the acute respiratory infection, but their prevalence declined rapidly during the mononucleosis. In contrast, CD8+ T cells specific for an H-2Kb-restricted epitope, apparently expressed by virus-infected B lymphocytes, were most numerous during the mononucleosis illness and were maintained at relatively high frequencies thereafter. The prevalence of all peptide-specific CD8+ T cells decreased during the expansion of the Vbeta4+ CD8+ population, which did not recognize any peptide epitopes identified and was apparent also in an MHC class I-deficient environment. The CD8+ T cell population recognizing productively infected epithelial cells thus differed substantially from that responding during the IM illness.}, address = {Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.}, author = {Stevenson, P. G. and Belz, G. T. and Altman, J. D. and Doherty, P. C.}, citeulike-article-id = {2651467}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10229071}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10229071}, issn = {0014-2980}, journal = {European journal of immunology}, keywords = {cell, epitope, mhv68, t}, month = {April}, number = {4}, pages = {1059--1067}, posted-at = {2008-04-11 04:15:29}, priority = {5}, title = {Changing patterns of dominance in the CD8+ T cell response during acute and persistent murine gamma-herpesvirus infection.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10229071}, volume = {29}, year = {1999} }

TY - JOUR ID - citeulike:2651467 L3 - citeulike-article-id:2651467 N2 - The murine gamma-herpesvirus MHV-68 causes an acute, transient pneumonitis, followed by an infectious mononucleosis (IM)-like illness with splenomegaly, widespread latent infection of B lymphocytes and an expansion of Vbeta4+ CD8+ T cells. CD8+ T cells specific for an H-2Db-restricted epitope were prominent during the acute respiratory infection, but their prevalence declined rapidly during the mononucleosis. In contrast, CD8+ T cells specific for an H-2Kb-restricted epitope, apparently expressed by virus-infected B lymphocytes, were most numerous during the mononucleosis illness and were maintained at relatively high frequencies thereafter. The prevalence of all peptide-specific CD8+ T cells decreased during the expansion of the Vbeta4+ CD8+ population, which did not recognize any peptide epitopes identified and was apparent also in an MHC class I-deficient environment. The CD8+ T cell population recognizing productively infected epithelial cells thus differed substantially from that responding during the IM illness. IS - 4 JF - European journal of immunology SN - 0014-2980 AD - Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. EP - 1067 TI - Changing patterns of dominance in the CD8+ T cell response during acute and persistent murine gamma-herpesvirus infection. VL - 29 SP - 1059 KW - cell KW - epitope KW - mhv68 KW - t AU - Stevenson, PG AU - Belz, GT AU - Altman, JD AU - Doherty, PC PY - 1999/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/10229071 ER -