Epstein-Barr virus BHRF1 functions downstream of Bid cleavage and upstream of mitochondrial dysfunction to inhibit TRAIL-induced apoptosis in BJAB cells Export

@article{citeulike:2693709, abstract = {We have previously reported that TNF-related apoptosis inducing ligand (TRAIL) causes cleavage of Bid via activation of caspase-8 and the loss of mitochondrial membrane potential ([Delta][Psi]m), resulting in apoptosis. Experiments with BJAB clones expressing Epstein-Barr virus (EBV) anti-apoptotic protein BHRF1 showed that BHRF1 drastically inhibited TRAIL-mediated apoptosis. Although Western blot analysis demonstrated that TRAIL-induced Bid cleavage was not inhibited by BHRF1, the decrease in [Delta][Psi]m caused by TRAIL was effectively blocked by BHRF1. These findings suggest that in BJAB cells, BHRF1 acts downstream of Bid cleavage and upstream of mitochondrial damage, resulting in inhibition of TRAIL-induced apoptosis.}, author = {Kawanishi, Michiko and Tada-Oikawa, Saeko and Kawanishi, Shosuke}, citeulike-article-id = {2693709}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0006-291X(02)02261-1}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WBK-46SNDFT-8/1/075bc6d97fd723ae1a6c0194f15c616d}, day = {27}, doi = {10.1016/S0006-291X(02)02261-1}, journal = {Biochemical and Biophysical Research Communications}, keywords = {bcl-2, caspase, ebv}, month = {September}, number = {3}, pages = {682--687}, posted-at = {2008-04-20 23:03:28}, priority = {4}, title = {Epstein-Barr virus BHRF1 functions downstream of Bid cleavage and upstream of mitochondrial dysfunction to inhibit TRAIL-induced apoptosis in BJAB cells}, url = {http://dx.doi.org/10.1016/S0006-291X(02)02261-1}, volume = {297}, year = {2002} }

TY - JOUR ID - citeulike:2693709 L3 - citeulike-article-id:2693709 N2 - We have previously reported that TNF-related apoptosis inducing ligand (TRAIL) causes cleavage of Bid via activation of caspase-8 and the loss of mitochondrial membrane potential ([Delta][Psi]m), resulting in apoptosis. Experiments with BJAB clones expressing Epstein-Barr virus (EBV) anti-apoptotic protein BHRF1 showed that BHRF1 drastically inhibited TRAIL-mediated apoptosis. Although Western blot analysis demonstrated that TRAIL-induced Bid cleavage was not inhibited by BHRF1, the decrease in [Delta][Psi]m caused by TRAIL was effectively blocked by BHRF1. These findings suggest that in BJAB cells, BHRF1 acts downstream of Bid cleavage and upstream of mitochondrial damage, resulting in inhibition of TRAIL-induced apoptosis. IS - 3 JF - Biochemical and Biophysical Research Communications EP - 687 TI - Epstein-Barr virus BHRF1 functions downstream of Bid cleavage and upstream of mitochondrial dysfunction to inhibit TRAIL-induced apoptosis in BJAB cells VL - 297 SP - 682 KW - bcl-2 KW - caspase KW - ebv AU - Kawanishi, Michiko AU - Tada-Oikawa, Saeko AU - Kawanishi, Shosuke PY - 2002/09/27/ UR - http://dx.doi.org/10.1016/S0006-291X(02)02261-1 ER -