A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon. Export

@article{citeulike:3054930, abstract = {Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon.}, author = {Sanchez, D. J. and Miranda, D. and Arumugaswami, V. and Hwang, S. and Singer, A. E. and Senaati, A. and Shahangian, A. and Song, M. J. and Sun, R. and Cheng, G.}, citeulike-article-id = {3054930}, citeulike-linkout-0 = {http://dx.doi.org/10.1128/JVI.01718-07}, citeulike-linkout-1 = {http://jvi.asm.org/cgi/content/abstract/82/5/2208}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18077715}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18077715}, day = {1}, doi = {10.1128/JVI.01718-07}, issn = {1098-5514}, journal = {Journal of virology}, keywords = {100bp-repeat, ifn, mhv68}, month = {March}, number = {5}, pages = {2208--2217}, posted-at = {2009-07-28 18:23:39}, priority = {0}, title = {A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon.}, url = {http://dx.doi.org/10.1128/JVI.01718-07}, volume = {82}, year = {2008} }

TY - JOUR ID - citeulike:3054930 L3 - citeulike-article-id:3054930 N2 - Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon. IS - 5 JF - Journal of virology SN - 1098-5514 EP - 2217 TI - A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon. VL - 82 SP - 2208 KW - 100bp-repeat KW - ifn KW - mhv68 AU - Sanchez, DJ AU - Miranda, D AU - Arumugaswami, V AU - Hwang, S AU - Singer, AE AU - Senaati, A AU - Shahangian, A AU - Song, MJ AU - Sun, R AU - Cheng, G PY - 2008/03/01/ UR - http://dx.doi.org/10.1128/JVI.01718-07 ER -