Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations. Export

@article{citeulike:3872396, abstract = {Infection of human B cells with Epstein-Barr virus (EBV) was seen to result in activation-induced cytidine deaminase (AID) and polymerase-eta (pol-eta) gene expression. AID and pol-eta are cellular gene products that play central roles in the DNA-modifying processes involved in immunoglobulin gene class switch recombination and somatic hypermutation. Errors in these processes can result in oncogene mutation/translocation, thereby contributing to lymphomagenesis. It was seen that EBV infected, AID, and pol-eta expressing B cells accumulated mutations in cellular proto-oncogenes (BCL-6 and p53) that are known to be involved in the genesis of B cell lymphoma. The nature of the mutations seen in these oncogenes was consistent with the known activity of AID and pol-eta. These findings indicate that EBV induced AID and pol-eta expression, and that this was associated with oncogene mutation, providing a novel means by which EBV infection of B cells may contribute to lymphomagenesis.}, author = {Epeldegui, M. and Hung, Y. P. and McQuay, A. and Ambinder, R. F. and Mart\'{\i}nez-Maza, O.}, citeulike-article-id = {3872396}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.molimm.2006.03.018}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16730063}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16730063}, doi = {10.1016/j.molimm.2006.03.018}, issn = {0161-5890}, journal = {Molecular immunology}, keywords = {aid, ebv}, month = {February}, number = {5}, pages = {934--942}, posted-at = {2009-01-09 20:34:04}, priority = {2}, title = {Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations.}, url = {http://dx.doi.org/10.1016/j.molimm.2006.03.018}, volume = {44}, year = {2007} }

TY - JOUR ID - citeulike:3872396 L3 - citeulike-article-id:3872396 N2 - Infection of human B cells with Epstein-Barr virus (EBV) was seen to result in activation-induced cytidine deaminase (AID) and polymerase-eta (pol-eta) gene expression. AID and pol-eta are cellular gene products that play central roles in the DNA-modifying processes involved in immunoglobulin gene class switch recombination and somatic hypermutation. Errors in these processes can result in oncogene mutation/translocation, thereby contributing to lymphomagenesis. It was seen that EBV infected, AID, and pol-eta expressing B cells accumulated mutations in cellular proto-oncogenes (BCL-6 and p53) that are known to be involved in the genesis of B cell lymphoma. The nature of the mutations seen in these oncogenes was consistent with the known activity of AID and pol-eta. These findings indicate that EBV induced AID and pol-eta expression, and that this was associated with oncogene mutation, providing a novel means by which EBV infection of B cells may contribute to lymphomagenesis. IS - 5 JF - Molecular immunology SN - 0161-5890 EP - 942 TI - Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations. VL - 44 SP - 934 KW - aid KW - ebv AU - Epeldegui, M AU - Hung, YP AU - McQuay, A AU - Ambinder, RF AU - Martínez-Maza, O PY - 2007/02// UR - http://dx.doi.org/10.1016/j.molimm.2006.03.018 ER -