Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Export

@article{citeulike:4872918, abstract = {BLyS (also called TALL-1, THANK, or BAFF) [1] [2] [3] [4] is a member of the tumor necrosis factor (TNF) gene family that stimulates proliferation and immunoglobulin production by B cells. BLyS interacts with the TNF receptor (TNFR) homologue TACI (transmembrane activator and CAML-interactor) [5], and treatment of mice with a TACI-Fc fusion protein abolishes germinal center formation after antigenic challenge [6]. Here we report a novel interaction between BLyS and another TNFR homologue, BCMA (B cell maturation antigen) [7] [8]. Further, the TNF homologue APRIL [9], a close relative of BLyS, also bound to BCMA and TACI. BLyS or APRIL activated nuclear factor-kappaB (NF-kappaB) through TACI and BCMA, and each ligand stimulated immunoglobulin M (IgM) production by peripheral blood B cells. These results define a dual ligand-receptor system that may play an important role in humoral immunity.}, author = {Marsters, S. A. and Yan, M. and Pitti, R. M. and Haas, P. E. and Dixit, V. M. and Ashkenazi, A.}, citeulike-article-id = {4872918}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10898980}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10898980}, day = {29}, issn = {0960-9822}, journal = {Current biology : CB}, keywords = {april, bcma}, month = {June}, number = {13}, pages = {785--788}, posted-at = {2009-06-16 19:22:43}, priority = {5}, title = {Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10898980}, volume = {10}, year = {2000} }

TY - JOUR ID - citeulike:4872918 L3 - citeulike-article-id:4872918 N2 - BLyS (also called TALL-1, THANK, or BAFF) [1] [2] [3] [4] is a member of the tumor necrosis factor (TNF) gene family that stimulates proliferation and immunoglobulin production by B cells. BLyS interacts with the TNF receptor (TNFR) homologue TACI (transmembrane activator and CAML-interactor) [5], and treatment of mice with a TACI-Fc fusion protein abolishes germinal center formation after antigenic challenge [6]. Here we report a novel interaction between BLyS and another TNFR homologue, BCMA (B cell maturation antigen) [7] [8]. Further, the TNF homologue APRIL [9], a close relative of BLyS, also bound to BCMA and TACI. BLyS or APRIL activated nuclear factor-kappaB (NF-kappaB) through TACI and BCMA, and each ligand stimulated immunoglobulin M (IgM) production by peripheral blood B cells. These results define a dual ligand-receptor system that may play an important role in humoral immunity. IS - 13 JF - Current biology : CB SN - 0960-9822 EP - 788 TI - Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. VL - 10 SP - 785 KW - april KW - bcma AU - Marsters, SA AU - Yan, M AU - Pitti, RM AU - Haas, PE AU - Dixit, VM AU - Ashkenazi, A PY - 2000/06/29/ UR - http://view.ncbi.nlm.nih.gov/pubmed/10898980 ER -