Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS. Export

@article{citeulike:321686, abstract = {BACKGROUND: In the era of highly active antiretroviral therapy (HAART) mortality has decreased substantially among human immunodeficiency virus (HIV)-infected people with access to HAART, but there are concerns regarding co-morbidities and adverse effects of HAART, which may impair vital prognosis. The Mortality 2000 study examined the causes of death in HIV-infected adults at a national level in France in the year 2000. METHODS: All French hospital wards known to be involved in the management of HIV infection were asked to notify prospectively the deaths that occurred in 2000 among HIV-infected adults. The causes of death were documented using a standardized questionnaire. RESULTS: The 185 participating wards notified 964 deaths. The main underlying causes of death were AIDS-related (47\%, non-Hodgkin's lymphoma: 23\%), viral hepatitis (11\%, hepatitis C: 9\%, hepatitis B: 2\%), cancer not related to AIDS or hepatitis (11\%), cardiovascular disease (7\%), bacterial infections (6\%), suicide (4\%), and adverse effect of antiretroviral treatments (1\%). Among AIDS-related deaths, HIV infection had been diagnosed recently in 20\%. Smoking was recorded in 72\% of cancer-related deaths and alcohol consumption in 54\% of hepatitis-related deaths. Among non-HIV related deaths between 25 and 64 years, the proportion of infectious diseases (including HCV and HBV-related deaths) was higher in HIV-infected adults than in the general population. CONCLUSIONS: Improved strategies for detecting HIV infection before AIDS-defining complications occur are needed in the era of HAART. The prevention of non-AIDS related cancers, especially lung cancer, the management of non-Hodgkin's lymphoma, and of viral hepatitis are also important priorities.}, address = {INSERM U593 (exU330), 146 rue L\'{e}o-Saignat, 33076 Bordeaux cedex, France.}, author = {Lewden, C. and Salmon, D. and Morlat, P. and B\'{e}vilacqua, S. and Jougla, E. and Bonnet, F. and H\'{e}ripret, L. and Costagliola, D. and May, T. and Ch\^{e}ne, G. and {}}, citeulike-article-id = {321686}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/15561752}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=15561752}, issn = {0300-5771}, journal = {Int J Epidemiol}, keywords = {haart, hcv, hiv, mortality}, month = {February}, number = {1}, pages = {121--130}, posted-at = {2006-09-21 19:03:26}, priority = {2}, title = {Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15561752}, volume = {34}, year = {2005} }

TY - JOUR ID - citeulike:321686 L3 - citeulike-article-id:321686 N2 - BACKGROUND: In the era of highly active antiretroviral therapy (HAART) mortality has decreased substantially among human immunodeficiency virus (HIV)-infected people with access to HAART, but there are concerns regarding co-morbidities and adverse effects of HAART, which may impair vital prognosis. The Mortality 2000 study examined the causes of death in HIV-infected adults at a national level in France in the year 2000. METHODS: All French hospital wards known to be involved in the management of HIV infection were asked to notify prospectively the deaths that occurred in 2000 among HIV-infected adults. The causes of death were documented using a standardized questionnaire. RESULTS: The 185 participating wards notified 964 deaths. The main underlying causes of death were AIDS-related (47%, non-Hodgkin's lymphoma: 23%), viral hepatitis (11%, hepatitis C: 9%, hepatitis B: 2%), cancer not related to AIDS or hepatitis (11%), cardiovascular disease (7%), bacterial infections (6%), suicide (4%), and adverse effect of antiretroviral treatments (1%). Among AIDS-related deaths, HIV infection had been diagnosed recently in 20%. Smoking was recorded in 72% of cancer-related deaths and alcohol consumption in 54% of hepatitis-related deaths. Among non-HIV related deaths between 25 and 64 years, the proportion of infectious diseases (including HCV and HBV-related deaths) was higher in HIV-infected adults than in the general population. CONCLUSIONS: Improved strategies for detecting HIV infection before AIDS-defining complications occur are needed in the era of HAART. The prevention of non-AIDS related cancers, especially lung cancer, the management of non-Hodgkin's lymphoma, and of viral hepatitis are also important priorities. IS - 1 JF - Int J Epidemiol SN - 0300-5771 AD - INSERM U593 (exU330), 146 rue Léo-Saignat, 33076 Bordeaux cedex, France. EP - 130 TI - Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS. VL - 34 SP - 121 KW - haart KW - hcv KW - hiv KW - mortality AU - Lewden, C AU - Salmon, D AU - Morlat, P AU - Bévilacqua, S AU - Jougla, E AU - Bonnet, F AU - Héripret, L AU - Costagliola, D AU - May, T AU - Chêne, G PY - 2005/02// UR - http://view.ncbi.nlm.nih.gov/pubmed/15561752 ER -