On multiscale approaches to three-dimensional modelling of morphogenesis. Export

@article{citeulike:2970592, abstract = {In this paper we present the foundation of a unified, object-oriented, three-dimensional biomodelling environment, which allows us to integrate multiple submodels at scales from subcellular to those of tissues and organs. Our current implementation combines a modified discrete model from statistical mechanics, the Cellular Potts Model, with a continuum reaction-diffusion model and a state automaton with well-defined conditions for cell differentiation transitions to model genetic regulation. This environment allows us to rapidly and compactly create computational models of a class of complex-developmental phenomena. To illustrate model development, we simulate a simplified version of the formation of the skeletal pattern in a growing embryonic vertebrate limb.}, address = {Department of Mathematics, Department of Physics and Center for the Study of Biocomplexity, University of Notre Dame, Notre Dame, IN 46556-5670, USA.}, author = {Chaturvedi, R. and Huang, C. and Kazmierczak, B. and Schneider, T. and Izaguirre, J. A. and Glimm, T. and Hentschel, H. G. and Glazier, J. A. and Newman, S. A. and Alber, M. S.}, citeulike-article-id = {2970592}, citeulike-linkout-0 = {http://dx.doi.org/10.1098/rsif.2005.0033}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16849182}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16849182}, day = {22}, doi = {10.1098/rsif.2005.0033}, issn = {1742-5689}, journal = {Journal of the Royal Society, Interface / the Royal Society}, keywords = {cpm, multiscale}, month = {June}, number = {3}, pages = {237--253}, posted-at = {2008-10-25 23:31:32}, priority = {2}, title = {On multiscale approaches to three-dimensional modelling of morphogenesis.}, url = {http://dx.doi.org/10.1098/rsif.2005.0033}, volume = {2}, year = {2005} }

TY - JOUR ID - citeulike:2970592 L3 - citeulike-article-id:2970592 N2 - In this paper we present the foundation of a unified, object-oriented, three-dimensional biomodelling environment, which allows us to integrate multiple submodels at scales from subcellular to those of tissues and organs. Our current implementation combines a modified discrete model from statistical mechanics, the Cellular Potts Model, with a continuum reaction-diffusion model and a state automaton with well-defined conditions for cell differentiation transitions to model genetic regulation. This environment allows us to rapidly and compactly create computational models of a class of complex-developmental phenomena. To illustrate model development, we simulate a simplified version of the formation of the skeletal pattern in a growing embryonic vertebrate limb. IS - 3 JF - Journal of the Royal Society, Interface / the Royal Society SN - 1742-5689 AD - Department of Mathematics, Department of Physics and Center for the Study of Biocomplexity, University of Notre Dame, Notre Dame, IN 46556-5670, USA. EP - 253 TI - On multiscale approaches to three-dimensional modelling of morphogenesis. VL - 2 SP - 237 KW - cpm KW - multiscale AU - Chaturvedi, R AU - Huang, C AU - Kazmierczak, B AU - Schneider, T AU - Izaguirre, JA AU - Glimm, T AU - Hentschel, HG AU - Glazier, JA AU - Newman, SA AU - Alber, MS PY - 2005/06/22/ UR - http://dx.doi.org/10.1098/rsif.2005.0033 ER -