Which DNA Damage is Likely to be Relevant in Hormetic Responses? Export

@article{citeulike:3451757, abstract = {Working under the assumption that hormesis is triggered by specific types of DNA damage, this report focuses on the types of damage which form the signature of ionizing radiation. The key attribute of the signature is the clustering of damage, arising from clusters of energy deposition such that more than one site within a 10 base pair segment of DNA has been chemically altered. A brief overview is given on what is currently believed to be the primary components of clustered damage produced by the direct effect. The overview draws primarily on studies that utilize electron paramagnetic resonance to measure free radical intermediates and gel electrophoresis to measure clustered damage in plasmid DNA. Based on this information, the threshold for a radiation induced biological response is calculated.}, author = {Bernhard, W. A. and Purkayastha, S. and Milligan, J. R.}, citeulike-article-id = {3451757}, citeulike-linkout-0 = {http://dx.doi.org/10.2203/dose-response.07-009.Bernhard}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18648576}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18648576}, doi = {10.2203/dose-response.07-009.Bernhard}, issn = {1559-3258}, journal = {Dose-response : a publication of International Hormesis Society}, keywords = {damage, dna, hormesis, radiation}, number = {2}, pages = {184--195}, posted-at = {2008-10-26 20:16:56}, priority = {2}, title = {Which DNA Damage is Likely to be Relevant in Hormetic Responses?}, url = {http://dx.doi.org/10.2203/dose-response.07-009.Bernhard}, volume = {6}, year = {2008} }

TY - JOUR ID - citeulike:3451757 L3 - citeulike-article-id:3451757 N2 - Working under the assumption that hormesis is triggered by specific types of DNA damage, this report focuses on the types of damage which form the signature of ionizing radiation. The key attribute of the signature is the clustering of damage, arising from clusters of energy deposition such that more than one site within a 10 base pair segment of DNA has been chemically altered. A brief overview is given on what is currently believed to be the primary components of clustered damage produced by the direct effect. The overview draws primarily on studies that utilize electron paramagnetic resonance to measure free radical intermediates and gel electrophoresis to measure clustered damage in plasmid DNA. Based on this information, the threshold for a radiation induced biological response is calculated. IS - 2 JF - Dose-response : a publication of International Hormesis Society SN - 1559-3258 EP - 195 TI - Which DNA Damage is Likely to be Relevant in Hormetic Responses? VL - 6 SP - 184 KW - damage KW - dna KW - hormesis KW - radiation AU - Bernhard, WA AU - Purkayastha, S AU - Milligan, JR PY - 2008/// UR - http://dx.doi.org/10.2203/dose-response.07-009.Bernhard ER -