A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies Export

@article{citeulike:912896, abstract = {BACKGROUND:Radiotherapy outcomes are usually predicted using the Linear Quadratic model. However, this model does not integrate complex features of tumor growth, in particular cell cycle regulation.METHODS:In this paper, we propose a multiscale model of cancer growth based on the genetic and molecular features of the evolution of colorectal cancer. The model includes key genes, cellular kinetics, tissue dynamics, macroscopic tumor evolution and radiosensitivity dependence on the cell cycle phase. We investigate the role of gene-dependent cell cycle regulation in the response of tumors to therapeutic irradiation protocols.RESULTS:Simulation results emphasize the importance of tumor tissue features and the need to consider regulating factors such as hypoxia, as well as tumor geometry and tissue dynamics, in predicting and improving radiotherapeutic efficacy.CONCLUSION:This model provides insight into the coupling of complex biological processes, which leads to a better understanding of oncogenesis. This will hopefully lead to improved irradiation therapy.}, author = {Ribba, Benjamin and Colin, Thierry and Schnell, Santiago}, citeulike-article-id = {912896}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/1742-4682-3-7}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16472396}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16472396}, doi = {10.1186/1742-4682-3-7}, journal = {Theoretical Biology and Medical Modelling}, keywords = {multiscale, radiation, tissue}, number = {1}, posted-at = {2008-10-25 23:17:20}, priority = {2}, title = {A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies}, url = {http://dx.doi.org/10.1186/1742-4682-3-7}, volume = {3}, year = {2006} }

TY - JOUR ID - citeulike:912896 L3 - citeulike-article-id:912896 N2 - BACKGROUND:Radiotherapy outcomes are usually predicted using the Linear Quadratic model. However, this model does not integrate complex features of tumor growth, in particular cell cycle regulation.METHODS:In this paper, we propose a multiscale model of cancer growth based on the genetic and molecular features of the evolution of colorectal cancer. The model includes key genes, cellular kinetics, tissue dynamics, macroscopic tumor evolution and radiosensitivity dependence on the cell cycle phase. We investigate the role of gene-dependent cell cycle regulation in the response of tumors to therapeutic irradiation protocols.RESULTS:Simulation results emphasize the importance of tumor tissue features and the need to consider regulating factors such as hypoxia, as well as tumor geometry and tissue dynamics, in predicting and improving radiotherapeutic efficacy.CONCLUSION:This model provides insight into the coupling of complex biological processes, which leads to a better understanding of oncogenesis. This will hopefully lead to improved irradiation therapy. IS - 1 JF - Theoretical Biology and Medical Modelling TI - A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies VL - 3 KW - multiscale KW - radiation KW - tissue AU - Ribba, Benjamin AU - Colin, Thierry AU - Schnell, Santiago PY - 2006/// UR - http://dx.doi.org/10.1186/1742-4682-3-7 ER -