The transcriptional consequences of mutation and natural selection in Caenorhabditis elegans Export

@article{citeulike:172861, abstract = {The evolutionary importance of gene-expression divergence is unclear: some studies suggest that it is an important mechanism for evolution by natural selection1, 2, whereas others claim that most between-species regulatory changes are neutral or nearly neutral3. We examined global transcriptional divergence patterns in a set of Caenorhabditis elegans mutation-accumulation lines and natural isolate lines to provide insights into the evolutionary importance of transcriptional variation and to discriminate between the forces of mutation and natural selection in shaping the evolution of gene expression. We detected the effects of selection on transcriptional divergence patterns and characterized them with respect to coexpressed gene sets, chromosomal clustering of expression changes and functional gene categories. We directly compared observed transcriptional variation patterns in the mutation-accumulation and natural isolate lines to a neutral model of transcriptome evolution to show that strong stabilizing selection dominates the evolution of transcriptional change for thousands of C. elegans expressed sequences.}, author = {Denver, Dee R. and Morris, Krystalynne and Streelman, J. Todd and Kim, Stuart K. and Lynch, Michael and Thomas, W. Kelley}, citeulike-article-id = {172861}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng1554}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng1554}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15852004}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15852004}, citeulike-linkout-4 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00025099}, day = {24}, doi = {10.1038/ng1554}, issn = {1061-4036}, journal = {Nature Genetics}, keywords = {c\_elegans, caenorhabditis\_elegans, expression\_evolution, mutation\_accumulation, stabilizing\_selection}, month = {April}, number = {5}, pages = {544--548}, posted-at = {2009-11-05 11:47:41}, priority = {3}, publisher = {Nature Publishing Group}, title = {The transcriptional consequences of mutation and natural selection in Caenorhabditis elegans}, url = {http://dx.doi.org/10.1038/ng1554}, volume = {37}, year = {2005} }

TY - JOUR ID - citeulike:172861 L3 - citeulike-article-id:172861 N2 - The evolutionary importance of gene-expression divergence is unclear: some studies suggest that it is an important mechanism for evolution by natural selection1, 2, whereas others claim that most between-species regulatory changes are neutral or nearly neutral3. We examined global transcriptional divergence patterns in a set of Caenorhabditis elegans mutation-accumulation lines and natural isolate lines to provide insights into the evolutionary importance of transcriptional variation and to discriminate between the forces of mutation and natural selection in shaping the evolution of gene expression. We detected the effects of selection on transcriptional divergence patterns and characterized them with respect to coexpressed gene sets, chromosomal clustering of expression changes and functional gene categories. We directly compared observed transcriptional variation patterns in the mutation-accumulation and natural isolate lines to a neutral model of transcriptome evolution to show that strong stabilizing selection dominates the evolution of transcriptional change for thousands of C. elegans expressed sequences. IS - 5 JF - Nature Genetics SN - 1061-4036 EP - 548 TI - The transcriptional consequences of mutation and natural selection in Caenorhabditis elegans PB - Nature Publishing Group VL - 37 SP - 544 KW - c_elegans KW - caenorhabditis_elegans KW - expression_evolution KW - mutation_accumulation KW - stabilizing_selection AU - Denver, Dee AU - Morris, Krystalynne AU - Streelman, Todd AU - Kim, Stuart AU - Lynch, Michael AU - Thomas, Kelley PY - 2005/04/24/ UR - http://dx.doi.org/10.1038/ng1554 ER -