Complex genetic interactions underlying expression differences between Drosophila races: analysis of chromosome substitutions. Export

@article{citeulike:2710083, abstract = {Regulation of gene expression is usually separated into cis and trans components. The separation may become artificial if much of the variation in expression is under multigenic and epistatic (e.g., cis-by-trans) control. There is hence a need to quantify the relative contribution of cis, trans, and cis-by-trans effects on expression divergence at different levels of evolution. To do so across the whole genome, we analyzed the full set of chromosome-substitution lines between the two behavioral races of Drosophila melanogaster. Our observations: (i) Only approximately 3\% of the genes with an expression difference are purely cis regulated. In fact, relatively few genes are governed by simple genetics because nearly 80\% of expression differences are controlled by at least two chromosomes. (ii) For 14\% of the genes, cis regulation does play a role but usually in conjunction with trans regulation. This joint action of cis and trans effects, either additive or epistatic, is referred to as inclusive cis effect. (iii) The percentage of genes with inclusive cis effect increases to 32\% among genes that are strongly differentiated between the two races. (iv) We observed a nonrandom distribution of trans-acting factors, with a substantial deficit on the second chromosome. Between Drosophila racial groups, trans regulation of expression difference is extensive, and cis regulation often evolves in conjunction with trans effects.}, author = {Wang, Hurng-Yi Y. and Fu, Yonggui and McPeek, Mary Sara S. and Lu, Xuemei and Nuzhdin, Sergey and Xu, Anlong and Lu, Jian and Wu, Mao-Lien L. and Wu, Chung-I I.}, citeulike-article-id = {2710083}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0711774105}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18430800}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18430800}, day = {29}, doi = {10.1073/pnas.0711774105}, issn = {1091-6490}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {drosophila, expression, expression\_evolution}, month = {April}, number = {17}, pages = {6362--6367}, posted-at = {2009-11-06 15:51:29}, priority = {2}, title = {Complex genetic interactions underlying expression differences between Drosophila races: analysis of chromosome substitutions.}, url = {http://dx.doi.org/10.1073/pnas.0711774105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:2710083 L3 - citeulike-article-id:2710083 N2 - Regulation of gene expression is usually separated into cis and trans components. The separation may become artificial if much of the variation in expression is under multigenic and epistatic (e.g., cis-by-trans) control. There is hence a need to quantify the relative contribution of cis, trans, and cis-by-trans effects on expression divergence at different levels of evolution. To do so across the whole genome, we analyzed the full set of chromosome-substitution lines between the two behavioral races of Drosophila melanogaster. Our observations: (i) Only approximately 3% of the genes with an expression difference are purely cis regulated. In fact, relatively few genes are governed by simple genetics because nearly 80% of expression differences are controlled by at least two chromosomes. (ii) For 14% of the genes, cis regulation does play a role but usually in conjunction with trans regulation. This joint action of cis and trans effects, either additive or epistatic, is referred to as inclusive cis effect. (iii) The percentage of genes with inclusive cis effect increases to 32% among genes that are strongly differentiated between the two races. (iv) We observed a nonrandom distribution of trans-acting factors, with a substantial deficit on the second chromosome. Between Drosophila racial groups, trans regulation of expression difference is extensive, and cis regulation often evolves in conjunction with trans effects. IS - 17 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 1091-6490 EP - 6367 TI - Complex genetic interactions underlying expression differences between Drosophila races: analysis of chromosome substitutions. VL - 105 SP - 6362 KW - drosophila KW - expression KW - expression_evolution AU - Wang, Hurng-Yi AU - Fu, Yonggui AU - McPeek, Mary Sara AU - Lu, Xuemei AU - Nuzhdin, Sergey AU - Xu, Anlong AU - Lu, Jian AU - Wu, Mao-Lien AU - Wu, Chung-I PY - 2008/04/29/ UR - http://dx.doi.org/10.1073/pnas.0711774105 ER -