Interchromosomal Interactions and Olfactory Receptor Choice Export

@article{citeulike:2550700, abstract = {Summary The expression of a single odorant receptor (OR) gene from a large gene family in individual sensory neurons is an essential feature of the organization and function of the olfactory system. We have used chromosome conformation capture to demonstrate the specific association of an enhancer element, H, on chromosome 14 with multiple OR gene promoters on different chromosomes. DNA and RNA fluorescence in situ hybridization (FISH) experiments allow us to visualize the colocalization of the H enhancer with the single OR allele that is transcribed in a sensory neuron. In transgenic mice bearing additional H elements, sensory neurons that express OR pseudogenes also express a second functional receptor. These data suggest a model of receptor choice in which a single trans-acting enhancer element may allow the stochastic activation of only one OR allele in an olfactory sensory neuron.}, author = {Lomvardas, Stavros and Barnea, Gilad and Pisapia, David J. and Mendelsohn, Monica and Kirkland, Jennifer and Axel, Richard}, citeulike-article-id = {2550700}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2006.06.035}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16873069}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16873069}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6WSN-4KH4DBN-S/2/b567bfb71b9196783ad46cd93107e0a6}, day = {28}, doi = {10.1016/j.cell.2006.06.035}, journal = {Cell}, keywords = {olfactory, regulation}, month = {July}, number = {2}, pages = {403--413}, posted-at = {2008-06-03 09:08:07}, priority = {2}, title = {Interchromosomal Interactions and Olfactory Receptor Choice}, url = {http://dx.doi.org/10.1016/j.cell.2006.06.035}, volume = {126}, year = {2006} }

TY - JOUR ID - citeulike:2550700 L3 - citeulike-article-id:2550700 N2 - Summary The expression of a single odorant receptor (OR) gene from a large gene family in individual sensory neurons is an essential feature of the organization and function of the olfactory system. We have used chromosome conformation capture to demonstrate the specific association of an enhancer element, H, on chromosome 14 with multiple OR gene promoters on different chromosomes. DNA and RNA fluorescence in situ hybridization (FISH) experiments allow us to visualize the colocalization of the H enhancer with the single OR allele that is transcribed in a sensory neuron. In transgenic mice bearing additional H elements, sensory neurons that express OR pseudogenes also express a second functional receptor. These data suggest a model of receptor choice in which a single trans-acting enhancer element may allow the stochastic activation of only one OR allele in an olfactory sensory neuron. IS - 2 JF - Cell EP - 413 TI - Interchromosomal Interactions and Olfactory Receptor Choice VL - 126 SP - 403 KW - olfactory KW - regulation AU - Lomvardas, Stavros AU - Barnea, Gilad AU - Pisapia, David AU - Mendelsohn, Monica AU - Kirkland, Jennifer AU - Axel, Richard PY - 2006/07/28/ UR - http://dx.doi.org/10.1016/j.cell.2006.06.035 ER -