Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals Export

@article{citeulike:3378913, abstract = {In bilaterian animals, such as humans, flies and worms, hundreds of microRNAs (miRNAs), some conserved throughout bilaterian evolution, collectively regulate a substantial fraction of the transcriptome. In addition to miRNAs, other bilaterian small RNAs, known as Piwi-interacting RNAs (piRNAs), protect the genome from transposons. Here we identify small RNAs from animal phyla that diverged before the emergence of the Bilateria. The cnidarian Nematostella vectensis (starlet sea anemone), a close relative to the Bilateria, possesses an extensive repertoire of miRNA genes, two classes of piRNAs and a complement of proteins specific to small-RNA biology comparable to that of humans. The poriferan Amphimedon queenslandica (sponge), one of the simplest animals and a distant relative of the Bilateria, also possesses miRNAs, both classes of piRNAs and a full complement of the small-RNA machinery. Animal miRNA evolution seems to have been relatively dynamic, with precursor sizes and mature miRNA sequences differing greatly between poriferans, cnidarians and bilaterians. Nonetheless, miRNAs and piRNAs have been available as classes of riboregulators to shape gene expression throughout the evolution and radiation of animal phyla.}, author = {Grimson, Andrew and Srivastava, Mansi and Fahey, Bryony and Woodcroft, Ben J. and Chiang, H. Rosaria and King, Nicole and Degnan, Bernard M. and Rokhsar, Daniel S. and Bartel, David P.}, citeulike-article-id = {3378913}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature07415}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature07415}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18830242}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18830242}, comment = {miRNA machinery appears to be present at the root of animal development. Chirag, check this for some basic methods on miRNA and piRNA detection/validation.}, day = {30}, doi = {10.1038/nature07415}, issn = {1476-4687}, journal = {Nature}, keywords = {evolution, mirna, nematostella, pirna}, month = {October}, number = {7217}, pages = {1193--1197}, posted-at = {2008-11-06 08:58:40}, priority = {4}, publisher = {Macmillan Publishers Limited. All rights reserved}, title = {Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals}, url = {http://dx.doi.org/10.1038/nature07415}, volume = {455}, year = {2008} }

TY - JOUR ID - citeulike:3378913 L3 - citeulike-article-id:3378913 N2 - In bilaterian animals, such as humans, flies and worms, hundreds of microRNAs (miRNAs), some conserved throughout bilaterian evolution, collectively regulate a substantial fraction of the transcriptome. In addition to miRNAs, other bilaterian small RNAs, known as Piwi-interacting RNAs (piRNAs), protect the genome from transposons. Here we identify small RNAs from animal phyla that diverged before the emergence of the Bilateria. The cnidarian Nematostella vectensis (starlet sea anemone), a close relative to the Bilateria, possesses an extensive repertoire of miRNA genes, two classes of piRNAs and a complement of proteins specific to small-RNA biology comparable to that of humans. The poriferan Amphimedon queenslandica (sponge), one of the simplest animals and a distant relative of the Bilateria, also possesses miRNAs, both classes of piRNAs and a full complement of the small-RNA machinery. Animal miRNA evolution seems to have been relatively dynamic, with precursor sizes and mature miRNA sequences differing greatly between poriferans, cnidarians and bilaterians. Nonetheless, miRNAs and piRNAs have been available as classes of riboregulators to shape gene expression throughout the evolution and radiation of animal phyla. IS - 7217 JF - Nature SN - 1476-4687 EP - 1197 TI - Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals PB - Macmillan Publishers Limited. All rights reserved VL - 455 SP - 1193 KW - evolution KW - mirna KW - nematostella KW - pirna N1 - miRNA machinery appears to be present at the root of animal development. Chirag, check this for some basic methods on miRNA and piRNA detection/validation. AU - Grimson, Andrew AU - Srivastava, Mansi AU - Fahey, Bryony AU - Woodcroft, Ben AU - Chiang, Rosaria AU - King, Nicole AU - Degnan, Bernard AU - Rokhsar, Daniel AU - Bartel, David PY - 2008/10/30/ UR - http://dx.doi.org/10.1038/nature07415 ER -