Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling. Export

@article{citeulike:267330, abstract = {Signal transduction in neurons is a dynamic process, generally thought to be driven by transient changes in the concentration of second messengers. Here we describe a novel regulatory mechanism in which the dynamics of signaling through cyclic AMP are mediated by activity-dependent changes in the affinity of the hyperpolarization-activated, cation nonselective (HCN) channels for cAMP, rather than by changes in cAMP concentration. Due to the allosteric coupling of channel opening and ligand binding, changes in cellular electrical activity that alter the opening of the HCN channels modify the binding of static, basal levels of cAMP. These changes in ligand binding produce long-lasting changes in channel function which can contribute to the regulation of rhythmic firing patterns.}, address = {Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University, 722 West 168 Street, New York, NY 10032, USA.}, author = {Wang, J. and Chen, S. and Nolan, M. F. and Siegelbaum, S. A.}, citeulike-article-id = {267330}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12408847}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12408847}, issn = {0896-6273}, journal = {Neuron}, keywords = {camp, channel, hcn, modulation}, month = {October}, number = {3}, pages = {451--461}, posted-at = {2009-01-14 14:57:44}, priority = {2}, title = {Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12408847}, volume = {36}, year = {2002} }

TY - JOUR ID - citeulike:267330 L3 - citeulike-article-id:267330 N2 - Signal transduction in neurons is a dynamic process, generally thought to be driven by transient changes in the concentration of second messengers. Here we describe a novel regulatory mechanism in which the dynamics of signaling through cyclic AMP are mediated by activity-dependent changes in the affinity of the hyperpolarization-activated, cation nonselective (HCN) channels for cAMP, rather than by changes in cAMP concentration. Due to the allosteric coupling of channel opening and ligand binding, changes in cellular electrical activity that alter the opening of the HCN channels modify the binding of static, basal levels of cAMP. These changes in ligand binding produce long-lasting changes in channel function which can contribute to the regulation of rhythmic firing patterns. IS - 3 JF - Neuron SN - 0896-6273 AD - Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University, 722 West 168 Street, New York, NY 10032, USA. EP - 461 TI - Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling. VL - 36 SP - 451 KW - camp KW - channel KW - hcn KW - modulation AU - Wang, J AU - Chen, S AU - Nolan, MF AU - Siegelbaum, SA PY - 2002/10/24/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12408847 ER -