Sensing voltage across lipid membranes Export

@article{citeulike:3803897, abstract = {The detection of electrical potentials across lipid bilayers by specialized membrane proteins is required for many fundamental cellular processes such as the generation and propagation of nerve impulses. These membrane proteins possess modular voltage-sensing domains, a notable example being the S1\&\#19;S4 domains of voltage-activated ion channels. Ground-breaking structural studies on these domains explain how voltage sensors are designed and reveal important interactions with the surrounding lipid membrane. Although further structures are needed to understand the conformational changes that occur during voltage sensing, the available data help to frame several key concepts that are fundamental to the mechanism of voltage sensing.}, author = {Swartz, Kenton J.}, citeulike-article-id = {3803897}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature07620}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature07620}, doi = {10.1038/nature07620}, issn = {0028-0836}, journal = {Nature}, keywords = {channel}, number = {7224}, pages = {891--897}, posted-at = {2009-02-04 11:24:04}, priority = {2}, publisher = {Nature Publishing Group}, title = {Sensing voltage across lipid membranes}, url = {http://dx.doi.org/10.1038/nature07620}, volume = {456} }

TY - JOUR ID - citeulike:3803897 L3 - citeulike-article-id:3803897 N2 - The detection of electrical potentials across lipid bilayers by specialized membrane proteins is required for many fundamental cellular processes such as the generation and propagation of nerve impulses. These membrane proteins possess modular voltage-sensing domains, a notable example being the S1S4 domains of voltage-activated ion channels. Ground-breaking structural studies on these domains explain how voltage sensors are designed and reveal important interactions with the surrounding lipid membrane. Although further structures are needed to understand the conformational changes that occur during voltage sensing, the available data help to frame several key concepts that are fundamental to the mechanism of voltage sensing. IS - 7224 JF - Nature SN - 0028-0836 EP - 897 TI - Sensing voltage across lipid membranes PB - Nature Publishing Group VL - 456 SP - 891 KW - channel AU - Swartz, Kenton UR - http://dx.doi.org/10.1038/nature07620 ER -