HCN hyperpolarization-activated cation channels inhibit EPSPs by interactions with M-type K(+) channels. Export

@article{citeulike:4365009, abstract = {The processing of synaptic potentials by neuronal dendrites depends on both their passive cable properties and active voltage-gated channels, which can generate complex effects as a result of their nonlinear properties. We characterized the actions of HCN (hyperpolarization-activated cyclic nucleotide-gated cation) channels on dendritic processing of subthreshold excitatory postsynaptic potentials (EPSPs) in mouse CA1 hippocampal neurons. The HCN channels generated an excitatory inward current (I(h)) that exerted a direct depolarizing effect on the peak voltage of weak EPSPs, but produced a paradoxical hyperpolarizing effect on the peak voltage of stronger, but still subthreshold, EPSPs. Using a combined modeling and experimental approach, we found that the inhibitory action of I(h) was caused by its interaction with the delayed-rectifier M-type K(+) current. In this manner, I(h) can enhance spike firing in response to an EPSP when spike threshold is low and can inhibit firing when spike threshold is high.}, author = {George, Meena S S. and Abbott, L F F. and Siegelbaum, Steven A A.}, citeulike-article-id = {4365009}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nn.2307}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nn.2307}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19363490}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19363490}, day = {12}, doi = {10.1038/nn.2307}, issn = {1546-1726}, journal = {Nature neuroscience}, keywords = {channel}, month = {April}, posted-at = {2009-05-08 12:14:10}, priority = {2}, title = {HCN hyperpolarization-activated cation channels inhibit EPSPs by interactions with M-type K(+) channels.}, url = {http://dx.doi.org/10.1038/nn.2307}, year = {2009} }

TY - JOUR ID - citeulike:4365009 L3 - citeulike-article-id:4365009 N2 - The processing of synaptic potentials by neuronal dendrites depends on both their passive cable properties and active voltage-gated channels, which can generate complex effects as a result of their nonlinear properties. We characterized the actions of HCN (hyperpolarization-activated cyclic nucleotide-gated cation) channels on dendritic processing of subthreshold excitatory postsynaptic potentials (EPSPs) in mouse CA1 hippocampal neurons. The HCN channels generated an excitatory inward current (I(h)) that exerted a direct depolarizing effect on the peak voltage of weak EPSPs, but produced a paradoxical hyperpolarizing effect on the peak voltage of stronger, but still subthreshold, EPSPs. Using a combined modeling and experimental approach, we found that the inhibitory action of I(h) was caused by its interaction with the delayed-rectifier M-type K(+) current. In this manner, I(h) can enhance spike firing in response to an EPSP when spike threshold is low and can inhibit firing when spike threshold is high. JF - Nature neuroscience SN - 1546-1726 TI - HCN hyperpolarization-activated cation channels inhibit EPSPs by interactions with M-type K(+) channels. KW - channel AU - George, Meena S AU - Abbott, L F AU - Siegelbaum, Steven A PY - 2009/04/12/ UR - http://dx.doi.org/10.1038/nn.2307 ER -