Neo-capsule tissue reactions in metal-on-metal hip arthroplasty. Export

@article{citeulike:6112368, abstract = {BACKGROUND: Modern-generation metal-on-metal articulations have a high wear resistance and may therefore be able to improve the long-term performance of artificial joints. However, the biological effects are still under debate. This study was undertaken to review the histopathological changes in neo-capsule tissues of different metal-on-metal hip arthroplasties. METHODS: Neo-capsule tissue samples from 46 hips with modern second-generation metal-on-metal articulations (39 hip resurfacings and 7 non-cemented total hip replacements) with a variety of failure mechanisms were examined histopathologically and immunohistochemically. RESULTS: A distinct lymphocytic infiltration was found in all cases with in situ times of more than 7 months, consisting of CD20-positive B-lymphocytes and CD3-positive T-lymphocytes and sometimes thinly distributed CD138-positive plasma cells without dominant T-cell or plasma cell infiltrates. INTERPRETATION: This distinct lymphocytic infiltration has not been reported in tissue analyses of metal- or ceramic-on-polyethylene hip replacements, and may therefore be considered to be a characteristic histological pattern of tissue reactions on metal particles and/or ions around metal-on-metal bearings.}, author = {Witzleb, Wolf-Christoph C. and Hanisch, Uwe and Kolar, Nicole and Krummenauer, Frank and Guenther, Klaus-Peter P.}, citeulike-article-id = {6112368}, citeulike-linkout-0 = {http://dx.doi.org/10.1080/17453670710013708}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17464609}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17464609}, doi = {10.1080/17453670710013708}, issn = {1745-3674}, journal = {Acta orthopaedica}, keywords = {metmet-bio}, month = {April}, number = {2}, pages = {211--220}, posted-at = {2009-11-14 23:33:04}, priority = {2}, title = {Neo-capsule tissue reactions in metal-on-metal hip arthroplasty.}, url = {http://dx.doi.org/10.1080/17453670710013708}, volume = {78}, year = {2007} }

TY - JOUR ID - citeulike:6112368 L3 - citeulike-article-id:6112368 N2 - BACKGROUND: Modern-generation metal-on-metal articulations have a high wear resistance and may therefore be able to improve the long-term performance of artificial joints. However, the biological effects are still under debate. This study was undertaken to review the histopathological changes in neo-capsule tissues of different metal-on-metal hip arthroplasties. METHODS: Neo-capsule tissue samples from 46 hips with modern second-generation metal-on-metal articulations (39 hip resurfacings and 7 non-cemented total hip replacements) with a variety of failure mechanisms were examined histopathologically and immunohistochemically. RESULTS: A distinct lymphocytic infiltration was found in all cases with in situ times of more than 7 months, consisting of CD20-positive B-lymphocytes and CD3-positive T-lymphocytes and sometimes thinly distributed CD138-positive plasma cells without dominant T-cell or plasma cell infiltrates. INTERPRETATION: This distinct lymphocytic infiltration has not been reported in tissue analyses of metal- or ceramic-on-polyethylene hip replacements, and may therefore be considered to be a characteristic histological pattern of tissue reactions on metal particles and/or ions around metal-on-metal bearings. IS - 2 JF - Acta orthopaedica SN - 1745-3674 EP - 220 TI - Neo-capsule tissue reactions in metal-on-metal hip arthroplasty. VL - 78 SP - 211 KW - metmet-bio AU - Witzleb, Wolf-Christoph AU - Hanisch, Uwe AU - Kolar, Nicole AU - Krummenauer, Frank AU - Guenther, Klaus-Peter PY - 2007/04// UR - http://dx.doi.org/10.1080/17453670710013708 ER -