The role of cytokine DNAs as vaccine adjuvants for optimizing cellular immune responses Export

@article{citeulike:1676630, abstract = {Summary: Cytokines represent a diverse group of immunologic effector and regulatory proteins that are critical components of the host response to invading pathogens. They have also been utilized as adjuvants to enhance immune responses to vaccines. In particular, plasmid cytokines have been studied extensively as candidate adjuvants for DNA vaccines in preclinical models and are now entering early-phase clinical trials. Here, we review recent advances in our understanding of cytokine biology, T-lymphocyte differentiation, and potential applications of plasmid cytokines in the rational design of improved vaccines.}, author = {Barouch, Dan H. and Letvin, Norman L. and Seder, Robert A.}, citeulike-article-id = {1676630}, citeulike-linkout-0 = {http://www.blackwell-synergy.com/doi/abs/10.1111/j.0105-2896.2004.00200.x}, citeulike-linkout-1 = {http://dx.doi.org/10.1111/j.0105-2896.2004.00200.x}, doi = {10.1111/j.0105-2896.2004.00200.x}, journal = {Immunological Reviews}, keywords = {cytokine, immunology, vaccine}, number = {1}, pages = {266--274}, posted-at = {2007-09-19 18:33:20}, priority = {2}, title = {The role of cytokine DNAs as vaccine adjuvants for optimizing cellular immune responses}, url = {http://dx.doi.org/10.1111/j.0105-2896.2004.00200.x}, volume = {202}, year = {2004} }

TY - JOUR ID - citeulike:1676630 L3 - citeulike-article-id:1676630 N2 - Summary: Cytokines represent a diverse group of immunologic effector and regulatory proteins that are critical components of the host response to invading pathogens. They have also been utilized as adjuvants to enhance immune responses to vaccines. In particular, plasmid cytokines have been studied extensively as candidate adjuvants for DNA vaccines in preclinical models and are now entering early-phase clinical trials. Here, we review recent advances in our understanding of cytokine biology, T-lymphocyte differentiation, and potential applications of plasmid cytokines in the rational design of improved vaccines. IS - 1 JF - Immunological Reviews EP - 274 TI - The role of cytokine DNAs as vaccine adjuvants for optimizing cellular immune responses VL - 202 SP - 266 KW - cytokine KW - immunology KW - vaccine AU - Barouch, Dan AU - Letvin, Norman AU - Seder, Robert PY - 2004/// UR - http://dx.doi.org/10.1111/j.0105-2896.2004.00200.x ER -