Global distribution of genomic diversity underscores rich complex history of continental human populations Export

@article{citeulike:4450743, abstract = {10.1101/gr.088898.108 Characterizing patterns of genetic variation within and among human populations is important for understanding human evolutionary history and for careful design of medical genetic studies. Here, we analyze patterns of variation across 443,434 single nucleotide polymorphisms (SNPs) genotyped in 3845 individuals from four continental regions. This unique resource allows us to illuminate patterns of diversity in previously under-studied populations at the genome-wide scale including Latin America, South Asia, and Southern Europe. Key insights afforded by our analysis include quantifying the degree of admixture in a large collection of individuals from Guadalajara, Mexico; identifying language and geography as key determinants of population structure within India; and elucidating a north\^{a}€“south gradient in haplotype diversity within Europe. We also present a novel method for identifying long-range tracts of homozygosity indicative of recent common ancestry. Application of our approach suggests great variation within and among populations in the extent of homozygosity, suggesting both demographic history (such as population bottlenecks) and recent ancestry events (such as consanguinity) play an important role in patterning variation in large modern human populations.}, author = {Auton, Adam and Bryc, Katarzyna and Boyko, Adam R. and Lohmueller, Kirk E. and Novembre, John and Reynolds, Andy and Indap, Amit and Wright, Mark H. and Degenhardt, Jeremiah D. and Gutenkunst, Ryan N. and King, Karen S. and Nelson, Matthew R. and Bustamante, Carlos D.}, citeulike-article-id = {4450743}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gr.088898.108}, citeulike-linkout-1 = {http://genome.cshlp.org/content/19/5/795.abstract}, citeulike-linkout-2 = {http://genome.cshlp.org/content/19/5/795.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19218534}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19218534}, doi = {10.1101/gr.088898.108}, issn = {1088-9051}, journal = {Genome Research}, keywords = {human, pop\_gen}, month = {May}, number = {5}, pages = {795--803}, posted-at = {2009-10-21 14:15:14}, priority = {2}, title = {Global distribution of genomic diversity underscores rich complex history of continental human populations}, url = {http://dx.doi.org/10.1101/gr.088898.108}, volume = {19}, year = {2009} }

TY - JOUR ID - citeulike:4450743 L3 - citeulike-article-id:4450743 N2 - 10.1101/gr.088898.108 Characterizing patterns of genetic variation within and among human populations is important for understanding human evolutionary history and for careful design of medical genetic studies. Here, we analyze patterns of variation across 443,434 single nucleotide polymorphisms (SNPs) genotyped in 3845 individuals from four continental regions. This unique resource allows us to illuminate patterns of diversity in previously under-studied populations at the genome-wide scale including Latin America, South Asia, and Southern Europe. Key insights afforded by our analysis include quantifying the degree of admixture in a large collection of individuals from Guadalajara, Mexico; identifying language and geography as key determinants of population structure within India; and elucidating a north–south gradient in haplotype diversity within Europe. We also present a novel method for identifying long-range tracts of homozygosity indicative of recent common ancestry. Application of our approach suggests great variation within and among populations in the extent of homozygosity, suggesting both demographic history (such as population bottlenecks) and recent ancestry events (such as consanguinity) play an important role in patterning variation in large modern human populations. IS - 5 JF - Genome Research SN - 1088-9051 EP - 803 TI - Global distribution of genomic diversity underscores rich complex history of continental human populations VL - 19 SP - 795 KW - human KW - pop_gen AU - Auton, Adam AU - Bryc, Katarzyna AU - Boyko, Adam AU - Lohmueller, Kirk AU - Novembre, John AU - Reynolds, Andy AU - Indap, Amit AU - Wright, Mark AU - Degenhardt, Jeremiah AU - Gutenkunst, Ryan AU - King, Karen AU - Nelson, Matthew AU - Bustamante, Carlos PY - 2009/05// UR - http://dx.doi.org/10.1101/gr.088898.108 ER -