Force Balance and Membrane Shedding at the Red-Blood-Cell Surface

by: Pierre Sens, Nir Gov

Physical Review Letters, Vol. 98, No. 1. (2007)

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Abstract

During the aging of the red-blood cell, or under conditions of extreme echinocytosis, membrane is shed from the cell plasma membrane in the form of nanovesicles. We propose that this process is the result of the self-adaptation of the membrane surface area to the elastic stress imposed by the spectrin cytoskeleton, via the local buckling of membrane under increasing cytoskeleton stiffness. This model introduces the concept of force balance as a regulatory process at the cell membrane and quantitatively reproduces the rate of area loss in aging red-blood cells.

@article{citeulike:2563595, abstract = {During the aging of the red-blood cell, or under conditions of extreme echinocytosis, membrane is shed from the cell plasma membrane in the form of nanovesicles. We propose that this process is the result of the self-adaptation of the membrane surface area to the elastic stress imposed by the spectrin cytoskeleton, via the local buckling of membrane under increasing cytoskeleton stiffness. This model introduces the concept of force balance as a regulatory process at the cell membrane and quantitatively reproduces the rate of area loss in aging red-blood cells.}, author = {Sens, Pierre and Gov, Nir }, citeulike-article-id = {2563595}, doi = {10.1103/PhysRevLett.98.018102}, journal = {Physical Review Letters}, keywords = {2007, biology, surface}, number = {1}, posted-at = {2008-03-19 17:27:25}, priority = {2}, publisher = {APS}, title = {Force Balance and Membrane Shedding at the Red-Blood-Cell Surface}, url = {http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal\&id=PRLTAO000098000001018102000001\&idtype=cvips\&gifs=yes}, volume = {98}, year = {2007} }

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TY - JOUR ID - citeulike:2563595 L3 - citeulike-article-id:2563595 TI - Force Balance and Membrane Shedding at the Red-Blood-Cell Surface JF - Physical Review Letters VL - 98 IS - 1 PB - APS N2 - During the aging of the red-blood cell, or under conditions of extreme echinocytosis, membrane is shed from the cell plasma membrane in the form of nanovesicles. We propose that this process is the result of the self-adaptation of the membrane surface area to the elastic stress imposed by the spectrin cytoskeleton, via the local buckling of membrane under increasing cytoskeleton stiffness. This model introduces the concept of force balance as a regulatory process at the cell membrane and quantitatively reproduces the rate of area loss in aging red-blood cells. KW - 2007 KW - biology KW - surface AU - Sens, Pierre AU - Gov, Nir PY - 2007/// UR - http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PRLTAO000098000001018102000001&idtype=cvips&gifs=yes ER -

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