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A finite-cluster phase in [small lambda]-DNA-coated colloids Export

Soft Matter, Vol. 3, No. 6. (2007), pp. 703-706.

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coating colloids dna phase poon

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We studied the aggregation of 1 [micro sign]m colloids bridged by DNA with 32 [micro sign]m contour length. We mixed two species of particles with grafted double-stranded [small lambda]-DNA displaying short, complementary single-stranded 'overhangs' as free binding-ends. Confocal microscopy showed the formation of stable, size-limited clusters in which the two species of particles were at touching contact. Simulations suggest that the observed close contact and the limitation to grow both result from entropic exclusion of the bridging DNA from the space between nearby particle surfaces.


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