The mouse A/HeJ Y chromosome: Another good Y gone bad

@article{citeulike:2963696, abstract = {Abstract\ \ In both humans and mice there are numerous reports of Y chromosome abnormalities that interfere with sex determination. Recent studies in the mouse of one such mutation have identified Y chromosome nondisjunction during preimplantation development as the cause of abnormal testis determination that results in a high frequency of true hermaphroditism. We report here that the mouse Y chromosome from the A/HeJ inbred strain induces similar aberrations in sex determination. Our analyses provide evidence, however, that the mechanism underlying these aberrations is not Y chromosome nondisjunction. On the basis of our findings, we postulate that a mutation at or near the centromere affects both the segregation and sex-determining properties of the A/HeJ Y chromosome. This Y chromosome adds to the growing list of Y chromosome aberrations in humans and mice. In both species, the centromere of the Y is structurally and morphologically distinct from the centromeres of all other chromosomes. We conclude that these centromeric features make the human and mouse Y chromosomes extremely sensitive to minor structural alterations, and that our studies provide yet another example of a good Y chromosome gone ‘bad.’}, author = {Hunt, Patricia and Jackson, Jodi and Horan, Sonia and Lawson, Crystal and Grindell, Laura and Washburn, Linda and Eicher, Eva }, citeulike-article-id = {2963696}, doi = {http://dx.doi.org/10.1007/s10577-008-1216-8}, journal = {Chromosome Research}, keywords = {y-chromosome}, month = {June}, number = {4}, pages = {623--636}, posted-at = {2008-07-04 12:45:44}, priority = {2}, title = {The mouse A/HeJ Y chromosome: Another good Y gone bad}, url = {http://dx.doi.org/10.1007/s10577-008-1216-8}, volume = {16}, year = {2008} }

TY - JOUR ID - citeulike:2963696 L3 - citeulike-article-id:2963696 TI - The mouse A/HeJ Y chromosome: Another good Y gone bad JF - Chromosome Research VL - 16 IS - 4 SP - 623 EP - 636 N2 - Abstract  In both humans and mice there are numerous reports of Y chromosome abnormalities that interfere with sex determination. Recent studies in the mouse of one such mutation have identified Y chromosome nondisjunction during preimplantation development as the cause of abnormal testis determination that results in a high frequency of true hermaphroditism. We report here that the mouse Y chromosome from the A/HeJ inbred strain induces similar aberrations in sex determination. Our analyses provide evidence, however, that the mechanism underlying these aberrations is not Y chromosome nondisjunction. On the basis of our findings, we postulate that a mutation at or near the centromere affects both the segregation and sex-determining properties of the A/HeJ Y chromosome. This Y chromosome adds to the growing list of Y chromosome aberrations in humans and mice. In both species, the centromere of the Y is structurally and morphologically distinct from the centromeres of all other chromosomes. We conclude that these centromeric features make the human and mouse Y chromosomes extremely sensitive to minor structural alterations, and that our studies provide yet another example of a good Y chromosome gone ‘bad.’ KW - y-chromosome AU - Hunt, Patricia AU - Jackson, Jodi AU - Horan, Sonia AU - Lawson, Crystal AU - Grindell, Laura AU - Washburn, Linda AU - Eicher, Eva PY - 2008/06/19/ UR - http://dx.doi.org/10.1007/s10577-008-1216-8 ER -