Mechanisms of sperm-egg interactions emerging from gene-manipulated animals. Export

@article{citeulike:3225575, abstract = {Sperm-egg interactions have been studied for many years using biochemical approaches such as the employment of antibodies and ligands that interact with sperm or with eggs and their vestments. As a result, various factors that participate in fertilization have emerged. However, when animals were genetically manipulated to examine the roles of those factors, most of them were found, to our surprise, to be "not essential". Of course, all biological systems contain redundancies and compensatory mechanisms, but at least some factors were found to be "essential" after gene disruption. As a whole, the explanations of sperm-egg interactions require significant modification from the gene manipulation point of view. In this review, information about sperm-egg interactions obtained from genetically manipulated animals is mainly revisited in order to propose a new vision.}, address = {Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.}, author = {Ikawa, M. and Inoue, N. and Okabe, M.}, citeulike-article-id = {3225575}, citeulike-linkout-0 = {http://dx.doi.org/10.1387/ijdb.072529mi}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18649279}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18649279}, doi = {10.1387/ijdb.072529mi}, issn = {0214-6282}, journal = {The International journal of developmental biology}, keywords = {sperm-egg-binding, sperm-egg-recognition, zona-pellucida}, number = {5-6}, pages = {657--664}, posted-at = {2008-09-11 14:50:25}, priority = {2}, title = {Mechanisms of sperm-egg interactions emerging from gene-manipulated animals.}, url = {http://dx.doi.org/10.1387/ijdb.072529mi}, volume = {52}, year = {2008} }

TY - JOUR ID - citeulike:3225575 L3 - citeulike-article-id:3225575 N2 - Sperm-egg interactions have been studied for many years using biochemical approaches such as the employment of antibodies and ligands that interact with sperm or with eggs and their vestments. As a result, various factors that participate in fertilization have emerged. However, when animals were genetically manipulated to examine the roles of those factors, most of them were found, to our surprise, to be "not essential". Of course, all biological systems contain redundancies and compensatory mechanisms, but at least some factors were found to be "essential" after gene disruption. As a whole, the explanations of sperm-egg interactions require significant modification from the gene manipulation point of view. In this review, information about sperm-egg interactions obtained from genetically manipulated animals is mainly revisited in order to propose a new vision. IS - 5-6 JF - The International journal of developmental biology SN - 0214-6282 AD - Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan. EP - 664 TI - Mechanisms of sperm-egg interactions emerging from gene-manipulated animals. VL - 52 SP - 657 KW - sperm-egg-binding KW - sperm-egg-recognition KW - zona-pellucida AU - Ikawa, M AU - Inoue, N AU - Okabe, M PY - 2008/// UR - http://dx.doi.org/10.1387/ijdb.072529mi ER -