Assisted reproductive technology and major structural birth defects in the United States Export

@article{citeulike:3816270, abstract = {BACKGROUNDWith >1\% of US births occurring following use of assisted reproductive technology (ART), it is critical to examine whether ART is associated with birth defects. METHODSWe analyzed data from the National Birth Defects Prevention Study, a population-based, multicenter, case-control study of birth defects. We included mothers of fetuses or live-born infants with a major birth defect (case infants) and mothers who had live-born infants who did not have a major birth defect (control infants), delivered during the period October 1997-December 2003. We compared mothers who reported ART use (IVF or ICSI) with those who had unassisted conceptions. Multiple logistic regression was used to adjust for the following confounders: maternal race/ethnicity, maternal age, smoking and parity; we stratified by plurality. RESULTSART was reported by 1.1\% of all control mothers, and by 4.5\% of control mothers 35 years or older. Among singleton births, ART was associated with septal heart defects (adjusted odds ratio [aOR] = 2.1, 95\% confidence intervals [CI] 1.1-4.0), cleft lip with or without cleft palate (aOR = 2.4, 95\% CI 1.2-5.1), esophageal atresia (aOR = 4.5, 95\% CI 1.9-10.5) and anorectal atresia (aOR = 3.7, 95\% CI 1.5-9.1). Among multiple births, ART was not significantly associated with any of the birth defects studied. CONCLUSIONSThese findings suggest that some birth defects occur more often among infants conceived with ART. Although the mechanism is not clear, couples considering ART should be informed of all potential risks and benefits. 10.1093/humrep/den387}, author = {Reefhuis, J. and Honein, M. A. and Schieve, L. A. and Correa, A. and Hobbs, C. A. and Rasmussen, S. A. and And}, citeulike-article-id = {3816270}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/humrep/den387}, citeulike-linkout-1 = {http://humrep.oxfordjournals.org/cgi/content/abstract/24/2/360?etoc}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19010807}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19010807}, day = {16}, doi = {10.1093/humrep/den387}, journal = {Hum. Reprod.}, keywords = {art, ivf}, month = {November}, pages = {den387+}, posted-at = {2009-01-15 13:51:32}, priority = {2}, title = {Assisted reproductive technology and major structural birth defects in the United States}, url = {http://dx.doi.org/10.1093/humrep/den387}, year = {2008} }

TY - JOUR ID - citeulike:3816270 L3 - citeulike-article-id:3816270 N2 - BACKGROUNDWith >1% of US births occurring following use of assisted reproductive technology (ART), it is critical to examine whether ART is associated with birth defects. METHODSWe analyzed data from the National Birth Defects Prevention Study, a population-based, multicenter, case-control study of birth defects. We included mothers of fetuses or live-born infants with a major birth defect (case infants) and mothers who had live-born infants who did not have a major birth defect (control infants), delivered during the period October 1997-December 2003. We compared mothers who reported ART use (IVF or ICSI) with those who had unassisted conceptions. Multiple logistic regression was used to adjust for the following confounders: maternal race/ethnicity, maternal age, smoking and parity; we stratified by plurality. RESULTSART was reported by 1.1% of all control mothers, and by 4.5% of control mothers 35 years or older. Among singleton births, ART was associated with septal heart defects (adjusted odds ratio [aOR] = 2.1, 95% confidence intervals [CI] 1.1-4.0), cleft lip with or without cleft palate (aOR = 2.4, 95% CI 1.2-5.1), esophageal atresia (aOR = 4.5, 95% CI 1.9-10.5) and anorectal atresia (aOR = 3.7, 95% CI 1.5-9.1). Among multiple births, ART was not significantly associated with any of the birth defects studied. CONCLUSIONSThese findings suggest that some birth defects occur more often among infants conceived with ART. Although the mechanism is not clear, couples considering ART should be informed of all potential risks and benefits. 10.1093/humrep/den387 JF - Hum. Reprod. TI - Assisted reproductive technology and major structural birth defects in the United States SP - den387 KW - art KW - ivf AU - Reefhuis, J AU - Honein, MA AU - Schieve, LA AU - Correa, A AU - Hobbs, CA AU - Rasmussen, SA AU - And PY - 2008/11/16/ UR - http://dx.doi.org/10.1093/humrep/den387 ER -