Mobile element-based forensic genomics. Export

@article{citeulike:6037825, abstract = {Mobile elements are commonly referred to as selfish repetitive DNA sequences. However, mobile elements represent a unique and underutilized group of molecular markers. Several of their characteristics make them ideally suited for use as tools in forensic genomic applications. These include their nature as essentially homoplasy-free characters, they are identical by descent, the ancestral state of any insertion is known to be the absence of the element, and many mobile element insertions are lineage specific. In this review, we provide an overview of mobile element biology and describe the application of certain mobile elements, especially the SINEs and other retrotransposons, to forensic genomics. These tools include quantitative species-specific DNA detection, analysis of complex biomaterials, and the inference of geographic origin of human DNA samples.}, author = {Ray, David A. and Walker, Jerilyn A. and Batzer, Mark A.}, citeulike-article-id = {6037825}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.mrfmmm.2006.11.019}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17161440}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17161440}, day = {1}, doi = {10.1016/j.mrfmmm.2006.11.019}, issn = {0027-5107}, journal = {Mutation research}, keywords = {forensic, retrotransposition, retrotransposon}, month = {March}, number = {1-2}, pages = {24--33}, posted-at = {2009-10-29 23:11:41}, priority = {2}, title = {Mobile element-based forensic genomics.}, url = {http://dx.doi.org/10.1016/j.mrfmmm.2006.11.019}, volume = {616}, year = {2007} }

TY - JOUR ID - citeulike:6037825 L3 - citeulike-article-id:6037825 N2 - Mobile elements are commonly referred to as selfish repetitive DNA sequences. However, mobile elements represent a unique and underutilized group of molecular markers. Several of their characteristics make them ideally suited for use as tools in forensic genomic applications. These include their nature as essentially homoplasy-free characters, they are identical by descent, the ancestral state of any insertion is known to be the absence of the element, and many mobile element insertions are lineage specific. In this review, we provide an overview of mobile element biology and describe the application of certain mobile elements, especially the SINEs and other retrotransposons, to forensic genomics. These tools include quantitative species-specific DNA detection, analysis of complex biomaterials, and the inference of geographic origin of human DNA samples. IS - 1-2 JF - Mutation research SN - 0027-5107 EP - 33 TI - Mobile element-based forensic genomics. VL - 616 SP - 24 KW - forensic KW - retrotransposition KW - retrotransposon AU - Ray, David AU - Walker, Jerilyn AU - Batzer, Mark PY - 2007/03/01/ UR - http://dx.doi.org/10.1016/j.mrfmmm.2006.11.019 ER -