Detecting Latency Differences in Event-Related BOLD Responses: Application to Words versus Nonwords and Initial versus Repeated Face Presentations Export

@article{citeulike:1466878, abstract = {We introduce a new method for detecting differences in the latency of blood oxygenation level-dependent (BOLD) responses to brief events within the context of the General Linear Model. Using a first-order Taylor approximation in terms of the temporal derivative of a canonical hemodynamic response function, statistical parametric maps of differential latencies were estimated via the ratio of derivative to canonical parameter estimates. This method was applied to two example datasets: comparison of words versus nonwords in a lexical decision task and initial versus repeated presentations of faces in a fame-judgment task. Tests across subjects revealed both magnitude and latency differences within several brain regions. This approach offers a computationally efficient means of detecting BOLD latency differences over the whole brain. Precise characterization of the hemodynamic latency and its interpretation in terms of underlying neural differences remain problematic, however.}, author = {Henson, R. N. A. and Price, C. J. and Rugg, M. D. and Turner, R. and Friston, K. J.}, citeulike-article-id = {1466878}, citeulike-linkout-0 = {http://www.sciencedirect.com/science/article/B6WNP-4575RNN-S/2/9e2389d1187390a6c2111a8a45cca4e3}, journal = {NeuroImage}, keywords = {fmri}, month = {January}, number = {1}, pages = {83--97}, posted-at = {2009-11-03 03:24:32}, priority = {2}, title = {Detecting Latency Differences in Event-Related BOLD Responses: Application to Words versus Nonwords and Initial versus Repeated Face Presentations}, url = {http://www.sciencedirect.com/science/article/B6WNP-4575RNN-S/2/9e2389d1187390a6c2111a8a45cca4e3}, volume = {15}, year = {2002} }

TY - JOUR ID - citeulike:1466878 L3 - citeulike-article-id:1466878 N2 - We introduce a new method for detecting differences in the latency of blood oxygenation level-dependent (BOLD) responses to brief events within the context of the General Linear Model. Using a first-order Taylor approximation in terms of the temporal derivative of a canonical hemodynamic response function, statistical parametric maps of differential latencies were estimated via the ratio of derivative to canonical parameter estimates. This method was applied to two example datasets: comparison of words versus nonwords in a lexical decision task and initial versus repeated presentations of faces in a fame-judgment task. Tests across subjects revealed both magnitude and latency differences within several brain regions. This approach offers a computationally efficient means of detecting BOLD latency differences over the whole brain. Precise characterization of the hemodynamic latency and its interpretation in terms of underlying neural differences remain problematic, however. IS - 1 JF - NeuroImage EP - 97 TI - Detecting Latency Differences in Event-Related BOLD Responses: Application to Words versus Nonwords and Initial versus Repeated Face Presentations VL - 15 SP - 83 KW - fmri AU - Henson, RNA AU - Price, CJ AU - Rugg, MD AU - Turner, R AU - Friston, KJ PY - 2002/01// UR - http://www.sciencedirect.com/science/article/B6WNP-4575RNN-S/2/9e2389d1187390a6c2111a8a45cca4e3 ER -