Control over brain activation and pain learned by using real-time functional MRI Export

@article{citeulike:3273418, abstract = {10.1073/pnas.0505210102 If an individual can learn to directly control activation of localized regions within the brain, this approach might provide control over the neurophysiological mechanisms that mediate behavior and cognition and could potentially provide a different route for treating disease. Control over the endogenous pain modulatory system is a particularly important target because it could enable a unique mechanism for clinical control over pain. Here, we found that by using real-time functional MRI (rtfMRI) to guide training, subjects were able to learn to control activation in the rostral anterior cingulate cortex (rACC), a region putatively involved in pain perception and regulation. When subjects deliberately induced increases or decreases in rACC fMRI activation, there was a corresponding change in the perception of pain caused by an applied noxious thermal stimulus. Control experiments demonstrated that this effect was not observed after similar training conducted without rtfMRI information, or using rtfMRI information derived from a different brain region, or sham rtfMRI information derived previously from a different subject. Chronic pain patients were also trained to control activation in rACC and reported decreases in the ongoing level of chronic pain after training. These findings show that individuals can gain voluntary control over activation in a specific brain region given appropriate training, that voluntary control over activation in rACC leads to control over pain perception, and that these effects were powerful enough to impact severe, chronic clinical pain.}, author = {Decharms, Christopher R. and Maeda, Fumiko and Glover, Gary H. and Ludlow, David and Pauly, John M. and Soneji, Deepak and Gabrieli, John D. and Mackey, Sean C.}, citeulike-article-id = {3273418}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0505210102}, citeulike-linkout-1 = {http://www.pnas.org/content/102/51/18626.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/102/51/18626.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/16352728}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=16352728}, day = {20}, doi = {10.1073/pnas.0505210102}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {fmri, functional\_imaging, pain, plasticity, real-time, therapy}, month = {December}, number = {51}, pages = {18626--18631}, posted-at = {2008-11-16 22:47:57}, priority = {0}, title = {Control over brain activation and pain learned by using real-time functional MRI}, url = {http://dx.doi.org/10.1073/pnas.0505210102}, volume = {102}, year = {2005} }

TY - JOUR ID - citeulike:3273418 L3 - citeulike-article-id:3273418 N2 - 10.1073/pnas.0505210102 If an individual can learn to directly control activation of localized regions within the brain, this approach might provide control over the neurophysiological mechanisms that mediate behavior and cognition and could potentially provide a different route for treating disease. Control over the endogenous pain modulatory system is a particularly important target because it could enable a unique mechanism for clinical control over pain. Here, we found that by using real-time functional MRI (rtfMRI) to guide training, subjects were able to learn to control activation in the rostral anterior cingulate cortex (rACC), a region putatively involved in pain perception and regulation. When subjects deliberately induced increases or decreases in rACC fMRI activation, there was a corresponding change in the perception of pain caused by an applied noxious thermal stimulus. Control experiments demonstrated that this effect was not observed after similar training conducted without rtfMRI information, or using rtfMRI information derived from a different brain region, or sham rtfMRI information derived previously from a different subject. Chronic pain patients were also trained to control activation in rACC and reported decreases in the ongoing level of chronic pain after training. These findings show that individuals can gain voluntary control over activation in a specific brain region given appropriate training, that voluntary control over activation in rACC leads to control over pain perception, and that these effects were powerful enough to impact severe, chronic clinical pain. IS - 51 JF - Proceedings of the National Academy of Sciences of the United States of America EP - 18631 TI - Control over brain activation and pain learned by using real-time functional MRI VL - 102 SP - 18626 KW - fmri KW - functional_imaging KW - pain KW - plasticity KW - real-time KW - therapy AU - Decharms, Christopher AU - Maeda, Fumiko AU - Glover, Gary AU - Ludlow, David AU - Pauly, John AU - Soneji, Deepak AU - Gabrieli, John AU - Mackey, Sean PY - 2005/12/20/ UR - http://dx.doi.org/10.1073/pnas.0505210102 ER -