Dissociation Of working memory from decision making within the human prefrontal cortex.

@article{citeulike:525382, abstract = {We tested the hypothesis that cognitive functions related to working memory (assessed with delay tasks) are distinct from those related to decision making (assessed with a gambling task), and that working memory and decision making depend in part on separate anatomical substrates. Normal controls (n = 21), subjects with lesions in the ventromedial (VM) (n = 9) or dorsolateral/high mesial (DL/M) prefrontal cortices (n = 10), performed on (1) modified delay tasks that assess working memory and (2) a gambling task designed to measure decision making. VM subjects with more anterior lesions (n = 4) performed defectively on the gambling but not the delay task. VM subjects with more posterior lesions (n = 5) were impaired on both tasks. Right DL/M subjects were impaired on the delay task but not the gambling task. Left DL/M subjects were not impaired on either task. The findings reveal a cognitive and anatomic double dissociation between deficits in decision making (anterior VM) and working memory (right DL/M). This presents the first direct evidence of such effects in humans using the lesion method and underscores the special importance of the VM prefrontal region in decision making, independent of a direct role in working memory.}, address = {Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa, 52242, USA.}, author = {Bechara, A. and Damasio, H. and Tranel, D. and Anderson, S. W. }, citeulike-article-id = {525382}, issn = {0270-6474}, journal = {J Neurosci}, keywords = {decisionmaking, pfc, workingmemory}, month = {January}, number = {1}, pages = {428--437}, posted-at = {2008-01-02 21:34:59}, priority = {2}, title = {Dissociation Of working memory from decision making within the human prefrontal cortex.}, url = {http://www.jneurosci.org/cgi/content/abstract/18/1/428}, volume = {18}, year = {1998} }

TY - JOUR ID - citeulike:525382 L3 - citeulike-article-id:525382 TI - Dissociation Of working memory from decision making within the human prefrontal cortex. JF - J Neurosci VL - 18 IS - 1 SP - 428 EP - 437 AD - Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa, 52242, USA. SN - 0270-6474 N2 - We tested the hypothesis that cognitive functions related to working memory (assessed with delay tasks) are distinct from those related to decision making (assessed with a gambling task), and that working memory and decision making depend in part on separate anatomical substrates. Normal controls (n = 21), subjects with lesions in the ventromedial (VM) (n = 9) or dorsolateral/high mesial (DL/M) prefrontal cortices (n = 10), performed on (1) modified delay tasks that assess working memory and (2) a gambling task designed to measure decision making. VM subjects with more anterior lesions (n = 4) performed defectively on the gambling but not the delay task. VM subjects with more posterior lesions (n = 5) were impaired on both tasks. Right DL/M subjects were impaired on the delay task but not the gambling task. Left DL/M subjects were not impaired on either task. The findings reveal a cognitive and anatomic double dissociation between deficits in decision making (anterior VM) and working memory (right DL/M). This presents the first direct evidence of such effects in humans using the lesion method and underscores the special importance of the VM prefrontal region in decision making, independent of a direct role in working memory. KW - decisionmaking KW - pfc KW - workingmemory AU - Bechara, A AU - Damasio, H AU - Tranel, D AU - Anderson, SW PY - 1998/01/01/ UR - http://www.jneurosci.org/cgi/content/abstract/18/1/428 ER -