Chemokines: multiple levels of leukocyte migration control*

by: Bernhard Moser, Marlene Wolf, Alfred Walz, Pius Loetscher

Trends in Immunology, Vol. 25, No. 2. (February 2004), pp. 75-84.

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Abstract

The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to leukocyte traffic. Chemokines are leukocyte attractants but also contribute to immune processes that do not directly involve leukocyte migration. Recent progress is most evident in the areas of lymphocyte development, immune response initiation and immune pathology. Important observations have also been reported on chemokine-receptor interactions, signal transduction and cellular responses. New insights into the role of chemokines in leukocyte attraction and relocation will be discussed, with emphasis on the distinct levels of leukocyte migration control that ultimately determine the performance of our immune defense system.

@article{citeulike:1676103, abstract = {The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to leukocyte traffic. Chemokines are leukocyte attractants but also contribute to immune processes that do not directly involve leukocyte migration. Recent progress is most evident in the areas of lymphocyte development, immune response initiation and immune pathology. Important observations have also been reported on chemokine-receptor interactions, signal transduction and cellular responses. New insights into the role of chemokines in leukocyte attraction and relocation will be discussed, with emphasis on the distinct levels of leukocyte migration control that ultimately determine the performance of our immune defense system.}, author = {Moser, Bernhard and Wolf, Marlene and Walz, Alfred and Loetscher, Pius }, citeulike-article-id = {1676103}, doi = {10.1016/j.it.2003.12.005}, journal = {Trends in Immunology}, keywords = {chemokines, migration}, month = {February}, number = {2}, pages = {75--84}, posted-at = {2007-09-19 15:02:06}, priority = {3}, title = {Chemokines: multiple levels of leukocyte migration control*}, url = {http://dx.doi.org/10.1016/j.it.2003.12.005}, volume = {25}, year = {2004} }

RIS record

TY - JOUR ID - citeulike:1676103 L3 - citeulike-article-id:1676103 TI - Chemokines: multiple levels of leukocyte migration control* JF - Trends in Immunology VL - 25 IS - 2 SP - 75 EP - 84 N2 - The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to leukocyte traffic. Chemokines are leukocyte attractants but also contribute to immune processes that do not directly involve leukocyte migration. Recent progress is most evident in the areas of lymphocyte development, immune response initiation and immune pathology. Important observations have also been reported on chemokine-receptor interactions, signal transduction and cellular responses. New insights into the role of chemokines in leukocyte attraction and relocation will be discussed, with emphasis on the distinct levels of leukocyte migration control that ultimately determine the performance of our immune defense system. KW - chemokines KW - migration AU - Moser, Bernhard AU - Wolf, Marlene AU - Walz, Alfred AU - Loetscher, Pius PY - 2004/02// UR - http://dx.doi.org/10.1016/j.it.2003.12.005 ER -

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