Polymerization and Bundling Kinetics of FtsZ Filaments☆ Export

@article{Lan_2008_BPJ, abstract = {FtsZ is a tubulin homolog essential for prokaryotic cell division. In living bacteria, FtsZ forms a ringlike structure (Z-ring) at the cell midpoint. Cell division coincides with a gradual contraction of the Z-ring, although the detailed molecular structure of the Z-ring is unknown. To reveal the structural properties of FtsZ, an understanding of FtsZ filament and bundle formation is needed. We develop a kinetic model that describes the polymerization and bundling mechanism of FtsZ filaments. The model reveals the energetics of the FtsZ filament formation and the bundling energy between filaments. A weak lateral interaction between filaments is predicted by the model. The model is able to fit the in vitro polymerization kinetics data of another researcher, and explains the cooperativity observed in FtsZ kinetics and the critical concentration in different buffer media. The developed model is also applicable for understanding the kinetics and energetics of other bundling biopolymer filaments.}, author = {Lan, G. and Dajkovic, A. and Wirtz, D. and Sun, S.}, citeulike-article-id = {5220962}, citeulike-linkout-0 = {http://dx.doi.org/10.1529/biophysj.108.132837}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0006349508785424}, day = {15}, doi = {10.1529/biophysj.108.132837}, issn = {00063495}, journal = {Biophysical Journal}, keywords = {2009\_nserc\_usra, biophysics, ftsz, kinetics, numerical\_simulation}, month = {October}, number = {8}, pages = {4045--4056}, posted-at = {2009-07-21 21:14:03}, priority = {2}, title = {Polymerization and Bundling Kinetics of FtsZ Filaments☆}, url = {http://dx.doi.org/10.1529/biophysj.108.132837}, volume = {95}, year = {2008} }

TY - JOUR ID - Lan_2008_BPJ L3 - citeulike-article-id:5220962 N2 - FtsZ is a tubulin homolog essential for prokaryotic cell division. In living bacteria, FtsZ forms a ringlike structure (Z-ring) at the cell midpoint. Cell division coincides with a gradual contraction of the Z-ring, although the detailed molecular structure of the Z-ring is unknown. To reveal the structural properties of FtsZ, an understanding of FtsZ filament and bundle formation is needed. We develop a kinetic model that describes the polymerization and bundling mechanism of FtsZ filaments. The model reveals the energetics of the FtsZ filament formation and the bundling energy between filaments. A weak lateral interaction between filaments is predicted by the model. The model is able to fit the in vitro polymerization kinetics data of another researcher, and explains the cooperativity observed in FtsZ kinetics and the critical concentration in different buffer media. The developed model is also applicable for understanding the kinetics and energetics of other bundling biopolymer filaments. IS - 8 JF - Biophysical Journal SN - 00063495 EP - 4056 TI - Polymerization and Bundling Kinetics of FtsZ Filaments☆ VL - 95 SP - 4045 KW - 2009_nserc_usra KW - biophysics KW - ftsz KW - kinetics KW - numerical_simulation AU - Lan, G AU - Dajkovic, A AU - Wirtz, D AU - Sun, S PY - 2008/10/15/ UR - http://dx.doi.org/10.1529/biophysj.108.132837 ER -