Dissecting protein-protein recognition sites Export

@article{citeulike:3385044, abstract = {The recognition sites in 70 pairwise protein-protein complexes of known three-dimensional structure are dissected in a set of surface patches by clustering atoms at the interface. When the interface buries \<2000 \r{A}2 of protein surface, the recognition sites usually form a single patch on the surface of each component protein. In contrast, larger interfaces are generally multipatch, with at least one pair of patches that are equivalent in size to a single-patch interface. Each recognition site, or patch within a site, contains a core made of buried interface atoms, surrounded by a rim of atoms that remain accessible to solvent in the complex. A simple geometric model reproduces the number and distribution of atoms within a patch. The rim is similar in composition to the rest of the protein surface, but the core has a distinctive amino acid composition, which may help in identifying potential protein recognition sites on single proteins of known structures. Proteins 2002;47:334-343. {\copyright} 2002 Wiley-Liss, Inc.}, address = {Department of Biochemistry, Bose Institute, P-1/12 CIT Scheme VIIM, Calcutta, India; Laboratoire d'Enzymologie et de Biochimie Structurales, CNRS UPR9063, Gif-sur-Yvette, France}, author = {Chakrabarti, Pinak and Janin, Jo\"{e}l}, citeulike-article-id = {3385044}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/prot.10085}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/92013192/ABSTRACT}, doi = {10.1002/prot.10085}, journal = {Proteins: Structure, Function, and Genetics}, keywords = {interactions, protein-protein}, number = {3}, pages = {334--343}, posted-at = {2009-01-08 20:58:41}, priority = {3}, title = {Dissecting protein-protein recognition sites}, url = {http://dx.doi.org/10.1002/prot.10085}, volume = {47}, year = {2002} }

TY - JOUR ID - citeulike:3385044 L3 - citeulike-article-id:3385044 N2 - The recognition sites in 70 pairwise protein-protein complexes of known three-dimensional structure are dissected in a set of surface patches by clustering atoms at the interface. When the interface buries <2000 Å2 of protein surface, the recognition sites usually form a single patch on the surface of each component protein. In contrast, larger interfaces are generally multipatch, with at least one pair of patches that are equivalent in size to a single-patch interface. Each recognition site, or patch within a site, contains a core made of buried interface atoms, surrounded by a rim of atoms that remain accessible to solvent in the complex. A simple geometric model reproduces the number and distribution of atoms within a patch. The rim is similar in composition to the rest of the protein surface, but the core has a distinctive amino acid composition, which may help in identifying potential protein recognition sites on single proteins of known structures. Proteins 2002;47:334-343. © 2002 Wiley-Liss, Inc. IS - 3 JF - Proteins: Structure, Function, and Genetics AD - Department of Biochemistry, Bose Institute, P-1/12 CIT Scheme VIIM, Calcutta, India; Laboratoire d'Enzymologie et de Biochimie Structurales, CNRS UPR9063, Gif-sur-Yvette, France EP - 343 TI - Dissecting protein-protein recognition sites VL - 47 SP - 334 KW - interactions KW - protein-protein AU - Chakrabarti, Pinak AU - Janin, Joël PY - 2002/// UR - http://dx.doi.org/10.1002/prot.10085 ER -