Development of secreted proteins as biotherapeutic agents. Export

@article{bonindebs:04, abstract = {As one of the most important classes of proteins, secreted factors account for about one-tenth of the human genome, 3000 - 4000 in total, including factors of signalling pathways, blood coagulation and immune defence, as well as digestive enzymes and components of the extracellular matrix. Secreted proteins are a rich source of new therapeutics and drug targets, and are currently the focus of major drug discovery programmes throughout the industry. Many of the most important novel drugs developed in biotechnology have resulted from the application of secreted proteins as therapeutics. Secreted proteins often circulate throughout the body and, therefore, have access to most organs and tissues. Because of that, many of the factors are themselves therapeutic agents. This paper gives an overview on the features and functions of human secreted proteins and peptides, as well as strategies by which to discover additional therapeutic proteins from the human 'secretome'. Furthermore, a variety of examples are provided for the therapeutic use of recombinant secreted proteins as 'biologicals', including features and applications of recombinant antibodies, erythropoietin, insulin, interferon, plasminogen activators, growth hormone and colony-stimulating factors.}, author = {Bonin-Debs, A. L. and Boche, I. and Gille, H. and Brinkmann, U.}, citeulike-article-id = {3866509}, citeulike-linkout-0 = {http://dx.doi.org/10.1517/14712598.4.4.551}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15102604}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15102604}, doi = {10.1517/14712598.4.4.551}, issn = {1471-2598}, journal = {Expert opinion on biological therapy}, keywords = {biopharmaceuticals, review}, month = {April}, number = {4}, pages = {551--558}, posted-at = {2009-01-09 02:11:41}, priority = {0}, title = {Development of secreted proteins as biotherapeutic agents.}, url = {http://dx.doi.org/10.1517/14712598.4.4.551}, volume = {4}, year = {2004} }

TY - JOUR ID - bonindebs:04 L3 - citeulike-article-id:3866509 N2 - As one of the most important classes of proteins, secreted factors account for about one-tenth of the human genome, 3000 - 4000 in total, including factors of signalling pathways, blood coagulation and immune defence, as well as digestive enzymes and components of the extracellular matrix. Secreted proteins are a rich source of new therapeutics and drug targets, and are currently the focus of major drug discovery programmes throughout the industry. Many of the most important novel drugs developed in biotechnology have resulted from the application of secreted proteins as therapeutics. Secreted proteins often circulate throughout the body and, therefore, have access to most organs and tissues. Because of that, many of the factors are themselves therapeutic agents. This paper gives an overview on the features and functions of human secreted proteins and peptides, as well as strategies by which to discover additional therapeutic proteins from the human 'secretome'. Furthermore, a variety of examples are provided for the therapeutic use of recombinant secreted proteins as 'biologicals', including features and applications of recombinant antibodies, erythropoietin, insulin, interferon, plasminogen activators, growth hormone and colony-stimulating factors. IS - 4 JF - Expert opinion on biological therapy SN - 1471-2598 EP - 558 TI - Development of secreted proteins as biotherapeutic agents. VL - 4 SP - 551 KW - biopharmaceuticals KW - review AU - Bonin-Debs, AL AU - Boche, I AU - Gille, H AU - Brinkmann, U PY - 2004/04// UR - http://dx.doi.org/10.1517/14712598.4.4.551 ER -