Flexible protein–protein docking Export

@article{citeulike:608530, abstract = {Predicting the structure of protein-protein complexes using docking approaches is a difficult problem whose major challenges include identifying correct solutions, and properly dealing with molecular flexibility and conformational changes. Flexibility can be addressed at several levels: implicitly, by smoothing the protein surfaces or allowing some degree of interpenetration (soft docking) or by performing multiple docking runs from various conformations (cross or ensemble docking); or explicitly, by allowing sidechain and/or backbone flexibility. Although significant improvements have been achieved in the modeling of sidechains, methods for the explicit inclusion of backbone flexibility in docking are still being developed. A few novel approaches have emerged involving collective degrees of motion, multicopy representations and multibody docking, which should allow larger conformational changes to be modeled.}, author = {BONVIN,, A}, booktitle = {Theory and simulation/Macromolecular assemblages - Joel Janin and Michael Levitt/Edward H Egelman and Andrew GW Leslie}, citeulike-article-id = {608530}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.sbi.2006.02.002}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0959440X06000315}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16488145}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16488145}, citeulike-linkout-4 = {http://www.sciencedirect.com/science/article/B6VS6-4J91R15-1/2/1ce10f3ef226ae1b30300842129a8d6c}, doi = {10.1016/j.sbi.2006.02.002}, issn = {0959440X}, journal = {Current Opinion in Structural Biology}, keywords = {haddock, pp-docking, pp-docking-flexible, pp-guided-docking}, month = {April}, number = {2}, pages = {194--200}, posted-at = {2006-07-07 08:12:17}, priority = {2}, title = {Flexible protein–protein docking}, url = {http://dx.doi.org/10.1016/j.sbi.2006.02.002}, volume = {16}, year = {2006} }

TY - JOUR ID - citeulike:608530 L3 - citeulike-article-id:608530 N2 - Predicting the structure of protein-protein complexes using docking approaches is a difficult problem whose major challenges include identifying correct solutions, and properly dealing with molecular flexibility and conformational changes. Flexibility can be addressed at several levels: implicitly, by smoothing the protein surfaces or allowing some degree of interpenetration (soft docking) or by performing multiple docking runs from various conformations (cross or ensemble docking); or explicitly, by allowing sidechain and/or backbone flexibility. Although significant improvements have been achieved in the modeling of sidechains, methods for the explicit inclusion of backbone flexibility in docking are still being developed. A few novel approaches have emerged involving collective degrees of motion, multicopy representations and multibody docking, which should allow larger conformational changes to be modeled. IS - 2 JF - Current Opinion in Structural Biology SN - 0959440X EP - 200 TI - Flexible protein–protein docking VL - 16 T2 - Theory and simulation/Macromolecular assemblages - Joel Janin and Michael Levitt/Edward H Egelman and Andrew GW Leslie SP - 194 KW - haddock KW - pp-docking KW - pp-docking-flexible KW - pp-guided-docking AU - BONVIN,, A PY - 2006/04// UR - http://dx.doi.org/10.1016/j.sbi.2006.02.002 ER -