Mechanisms to control rereplication and implications for cancer. Export

@article{citeulike:3707256, abstract = {Recent advances in the replication field have highlighted how the replication initiator proteins are negatively regulated by inhibitor proteins and ubiquitin-mediated degradation in mammalian cells to prevent rereplication. When these regulatory pathways go awry, uncontrolled rereplication ensues and a G2/M checkpoint is evoked to prevent cellular death. Many components of the checkpoints activated by rereplicaton are important for cancer prevention by facilitating DNA damage repair processes. The pathways that prevent rereplication themselves have also recently been implicated in preventing tumorigenesis. Studies from patient tumors, genetically altered mice, and mammalian cell culture suggest that deregulation of replication licensing proteins results in an increase in aneuploidy, chromosomal fusions, and DNA breaks. These studies provide a framework to address how regulators of replication function to maintain genomic stability.}, author = {Hook, Sara S. and Lin, Jie Jessie J. and Dutta, Anindya}, citeulike-article-id = {3707256}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ceb.2007.10.007}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0955067407001524}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18053699}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18053699}, doi = {10.1016/j.ceb.2007.10.007}, issn = {0955-0674}, journal = {Current opinion in cell biology}, keywords = {checkpoint, dna, replication, review}, month = {December}, number = {6}, pages = {663--671}, posted-at = {2009-10-10 21:30:56}, priority = {2}, title = {Mechanisms to control rereplication and implications for cancer.}, url = {http://dx.doi.org/10.1016/j.ceb.2007.10.007}, volume = {19}, year = {2007} }

TY - JOUR ID - citeulike:3707256 L3 - citeulike-article-id:3707256 N2 - Recent advances in the replication field have highlighted how the replication initiator proteins are negatively regulated by inhibitor proteins and ubiquitin-mediated degradation in mammalian cells to prevent rereplication. When these regulatory pathways go awry, uncontrolled rereplication ensues and a G2/M checkpoint is evoked to prevent cellular death. Many components of the checkpoints activated by rereplicaton are important for cancer prevention by facilitating DNA damage repair processes. The pathways that prevent rereplication themselves have also recently been implicated in preventing tumorigenesis. Studies from patient tumors, genetically altered mice, and mammalian cell culture suggest that deregulation of replication licensing proteins results in an increase in aneuploidy, chromosomal fusions, and DNA breaks. These studies provide a framework to address how regulators of replication function to maintain genomic stability. IS - 6 JF - Current opinion in cell biology SN - 0955-0674 EP - 671 TI - Mechanisms to control rereplication and implications for cancer. VL - 19 SP - 663 KW - checkpoint KW - dna KW - replication KW - review AU - Hook, Sara AU - Lin, Jie Jessie AU - Dutta, Anindya PY - 2007/12// UR - http://dx.doi.org/10.1016/j.ceb.2007.10.007 ER -