Characteristics of interpolyelectrolyte complexes of Eudragit E100 with Eudragit L100 Export

@article{citeulike:2620703, abstract = {With a view to the application in oral controlled drug delivery systems, the formation of interpolyelectrolyte complexes (IPEC) between Eudragit E100 (EE) and Eudragit L100 (EL) was investigated, using turbidimetry, solution viscosity measurements and elementary analysis. The structure of the synthesized IPEC was investigated by using FT-IR spectroscopy. The binding ratio of a unit molecule of EL with EE was found to be approximately 1:1 in pH 6.0. Based on the results of elementary analysis, and FT-IR, the binding ratio of each component in the solid complexes was very close to that observed in turbidity and viscosity measurements and indicate that the synthesized products can be considered as IPEC. Due to the structure of the IPEC, two maxima were observed in the swelling behaviour as a function of pH. The release of the model drug ibuprofen was significantly retarded from tablets made up of the IPEC.}, author = {Moustafine, R. I. and Kabanova, T. V. and Kemenova, V. A. and Van den Mooter, G.}, citeulike-article-id = {2620703}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jconrel.2004.11.031}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T3D-4F7S11J-1/2/0624ad558e61947cf9b8c3708f68a164}, day = {2}, doi = {10.1016/j.jconrel.2004.11.031}, journal = {Journal of Controlled Release}, keywords = {combinations, russian}, month = {March}, number = {1}, pages = {191--198}, posted-at = {2008-04-01 19:03:40}, priority = {2}, title = {Characteristics of interpolyelectrolyte complexes of Eudragit E100 with Eudragit L100}, url = {http://dx.doi.org/10.1016/j.jconrel.2004.11.031}, volume = {103}, year = {2005} }

TY - JOUR ID - citeulike:2620703 L3 - citeulike-article-id:2620703 N2 - With a view to the application in oral controlled drug delivery systems, the formation of interpolyelectrolyte complexes (IPEC) between Eudragit E100 (EE) and Eudragit L100 (EL) was investigated, using turbidimetry, solution viscosity measurements and elementary analysis. The structure of the synthesized IPEC was investigated by using FT-IR spectroscopy. The binding ratio of a unit molecule of EL with EE was found to be approximately 1:1 in pH 6.0. Based on the results of elementary analysis, and FT-IR, the binding ratio of each component in the solid complexes was very close to that observed in turbidity and viscosity measurements and indicate that the synthesized products can be considered as IPEC. Due to the structure of the IPEC, two maxima were observed in the swelling behaviour as a function of pH. The release of the model drug ibuprofen was significantly retarded from tablets made up of the IPEC. IS - 1 JF - Journal of Controlled Release EP - 198 TI - Characteristics of interpolyelectrolyte complexes of Eudragit E100 with Eudragit L100 VL - 103 SP - 191 KW - combinations KW - russian AU - Moustafine, RI AU - Kabanova, TV AU - Kemenova, VA AU - Van den Mooter, G PY - 2005/03/02/ UR - http://dx.doi.org/10.1016/j.jconrel.2004.11.031 ER -