Statistical optimization of a sustained-release matrix tablet of lobenzarit disodium. Export

@article{citeulike:490322, abstract = {The statistical optimization of sustained-release matrix tablets of lobenzarit disodium salt (LDS) was performed using the central composite experiment design 2(3) for three independent variables: the amount of polymer (Eudragit RS-PO) AP, the total volume of granulation solvent VS, and the amount of filler (microcrystalline cellulose) CE. The t90\% was selected as the response variable. The response surfaces were performed from a statistical mathematical model. The optimal formulation was obtained for the variables (AP = 15 mg, VS = 60 microliters, and CE = 0).}, address = {Department of Chemical Synthesis, Center of Pharmaceutical Chemistry, Havana, Cuba.}, author = {Boza, A. and De la Cruz, Y. and Jord\'{a}n, G. and J\'{a}uregui-Haza, U. and Alem\'{a}n, A. and Caraballo, I.}, citeulike-article-id = {490322}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11147132}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11147132}, issn = {0363-9045}, journal = {Drug Dev Ind Pharm}, keywords = {25082005, presentacion}, month = {December}, number = {12}, pages = {1303--1307}, posted-at = {2006-02-03 09:35:18}, priority = {0}, title = {Statistical optimization of a sustained-release matrix tablet of lobenzarit disodium.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11147132}, volume = {26}, year = {2000} }

TY - JOUR ID - citeulike:490322 L3 - citeulike-article-id:490322 N2 - The statistical optimization of sustained-release matrix tablets of lobenzarit disodium salt (LDS) was performed using the central composite experiment design 2(3) for three independent variables: the amount of polymer (Eudragit RS-PO) AP, the total volume of granulation solvent VS, and the amount of filler (microcrystalline cellulose) CE. The t90% was selected as the response variable. The response surfaces were performed from a statistical mathematical model. The optimal formulation was obtained for the variables (AP = 15 mg, VS = 60 microliters, and CE = 0). IS - 12 JF - Drug Dev Ind Pharm SN - 0363-9045 AD - Department of Chemical Synthesis, Center of Pharmaceutical Chemistry, Havana, Cuba. EP - 1307 TI - Statistical optimization of a sustained-release matrix tablet of lobenzarit disodium. VL - 26 SP - 1303 KW - 25082005 KW - presentacion AU - Boza, A AU - De la Cruz, Y AU - Jordán, G AU - Jáuregui-Haza, U AU - Alemán, A AU - Caraballo, I PY - 2000/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/11147132 ER -