Manufacture of slow-release matrix granules by wet granulation with an aqueous dispersion of quaternary poly(meth)acrylates in the fluidized bed. Export

@article{citeulike:490692, abstract = {Slow-release matrix granules were manufactured in the fluidized bed using an aqueous dispersion of quaternary poly(meth)acrylates (Eudragit RS 30 D) as binder for granulation. A factorial design was carried out to investigate the influence of the following parameters, spraying rate, applied polymer amount, and inlet air temperature, on various granule properties. Prerequisites for a slow release of the model drug theophylline are high spraying rate, high amount of polymer, and low inlet air temperature. No considerable decrease of the drug release rate can be achieved without a subsequent curing of the dry granules. A clear correlation exists between the moisture content of the fluidized bed, indicated by the terminal moisture content (TMC), and the mean dissolution time for 80\% of the drug (MDT80).}, address = {Pharmaceutical Research \& Development, Boehringer Ingelheim Pharma KG, Biberach/Riss, Germany.}, author = {Radtke, G. and Knop, K. and Lippold, B. C.}, citeulike-article-id = {490692}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12476875}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12476875}, issn = {0363-9045}, journal = {Drug Dev Ind Pharm}, keywords = {25082005, presentacion}, month = {November}, number = {10}, pages = {1295--1302}, posted-at = {2006-02-03 09:41:26}, priority = {0}, title = {Manufacture of slow-release matrix granules by wet granulation with an aqueous dispersion of quaternary poly(meth)acrylates in the fluidized bed.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12476875}, volume = {28}, year = {2002} }

TY - JOUR ID - citeulike:490692 L3 - citeulike-article-id:490692 N2 - Slow-release matrix granules were manufactured in the fluidized bed using an aqueous dispersion of quaternary poly(meth)acrylates (Eudragit RS 30 D) as binder for granulation. A factorial design was carried out to investigate the influence of the following parameters, spraying rate, applied polymer amount, and inlet air temperature, on various granule properties. Prerequisites for a slow release of the model drug theophylline are high spraying rate, high amount of polymer, and low inlet air temperature. No considerable decrease of the drug release rate can be achieved without a subsequent curing of the dry granules. A clear correlation exists between the moisture content of the fluidized bed, indicated by the terminal moisture content (TMC), and the mean dissolution time for 80% of the drug (MDT80). IS - 10 JF - Drug Dev Ind Pharm SN - 0363-9045 AD - Pharmaceutical Research & Development, Boehringer Ingelheim Pharma KG, Biberach/Riss, Germany. EP - 1302 TI - Manufacture of slow-release matrix granules by wet granulation with an aqueous dispersion of quaternary poly(meth)acrylates in the fluidized bed. VL - 28 SP - 1295 KW - 25082005 KW - presentacion AU - Radtke, G AU - Knop, K AU - Lippold, BC PY - 2002/11// UR - http://view.ncbi.nlm.nih.gov/pubmed/12476875 ER -