The role of the kneading paddle and the effects of screw revolution speed and water content on the preparation of solid dispersions using a twin-screw extruder Export

@article{citeulike:490856, abstract = {The twin-screw hot-melt extrusion process is useful for preparing solid dispersions which can improve the dissolution and absorption of drugs. The kneading paddle elements of the screws play an important role in changing the crystallinity and dissolution properties of a solid dispersion of kneaded nifedipine-hydroxypropylmethylcellulose phthalate (NP-HPMCP). After operating the machine, a small amount of kneaded material adhereing to the screws was collected and its physicochemical properties examined. Samples from the kneading paddle with a twist angle of 60[deg] were transparent and exhibited super-saturation on dissolution testing. When the kneading paddle elements were detached from the screws and only the feed screw elements were operated, the physicochemical properties of the extruded material were significantly influenced by the operating conditions of the machine e.g. revolution rate of screws, and the amount of water added to the feed materials. Slow revolution of the screws and the addition of a suitable amount of water to the mixture increased the rate of drug dissolution, although no super-saturation occurred. As the kneading paddle elements can retain the mixture in the machine for a longer period under intense shear, desired solid dispersions can be prepared routinely irrespective of the operating conditions. Moreover, a capillary rheometer can be useful to predetermine the amount of water added and the temperature for the preparation of solid dispersions using a twin-screw extruder.}, author = {Nakamichi, Kouichi and Nakano, Tomio and Yasuura, Hiroyuki and Izumi, Shogo and Kawashima, Yoshiaki}, citeulike-article-id = {490856}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0378-5173(02)00134-5}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T7W-45XT6N2-5/2/183baed7efe412e73e5023f8ad6bf902}, day = {25}, doi = {10.1016/S0378-5173(02)00134-5}, journal = {International Journal of Pharmaceutics}, keywords = {extrusion, hot, melt}, month = {July}, number = {2}, pages = {203--211}, posted-at = {2006-02-03 10:03:07}, priority = {3}, title = {The role of the kneading paddle and the effects of screw revolution speed and water content on the preparation of solid dispersions using a twin-screw extruder}, url = {http://dx.doi.org/10.1016/S0378-5173(02)00134-5}, volume = {241}, year = {2002} }

TY - JOUR ID - citeulike:490856 L3 - citeulike-article-id:490856 N2 - The twin-screw hot-melt extrusion process is useful for preparing solid dispersions which can improve the dissolution and absorption of drugs. The kneading paddle elements of the screws play an important role in changing the crystallinity and dissolution properties of a solid dispersion of kneaded nifedipine-hydroxypropylmethylcellulose phthalate (NP-HPMCP). After operating the machine, a small amount of kneaded material adhereing to the screws was collected and its physicochemical properties examined. Samples from the kneading paddle with a twist angle of 60[deg] were transparent and exhibited super-saturation on dissolution testing. When the kneading paddle elements were detached from the screws and only the feed screw elements were operated, the physicochemical properties of the extruded material were significantly influenced by the operating conditions of the machine e.g. revolution rate of screws, and the amount of water added to the feed materials. Slow revolution of the screws and the addition of a suitable amount of water to the mixture increased the rate of drug dissolution, although no super-saturation occurred. As the kneading paddle elements can retain the mixture in the machine for a longer period under intense shear, desired solid dispersions can be prepared routinely irrespective of the operating conditions. Moreover, a capillary rheometer can be useful to predetermine the amount of water added and the temperature for the preparation of solid dispersions using a twin-screw extruder. IS - 2 JF - International Journal of Pharmaceutics EP - 211 TI - The role of the kneading paddle and the effects of screw revolution speed and water content on the preparation of solid dispersions using a twin-screw extruder VL - 241 SP - 203 KW - extrusion KW - hot KW - melt AU - Nakamichi, Kouichi AU - Nakano, Tomio AU - Yasuura, Hiroyuki AU - Izumi, Shogo AU - Kawashima, Yoshiaki PY - 2002/07/25/ UR - http://dx.doi.org/10.1016/S0378-5173(02)00134-5 ER -