Fabrication of multiunit controlled-release phenylpropanolamine hydrochloride tablets. Export

@article{citeulike:493441, abstract = {Phenylpropanolamine hydrochloride (PPA) pellets were prepared in a fluidized-bed rotary granulator. Microcrystalline cellulose and distilled water were used as pelletization enhancer and binder, respectively. The pellets were coated with methacrylate ester copolymer (Eudragit RS 100) solution containing a 1:1 ratio mixture of triethyl citrate and castor oil as plasticizers. The addition of approximately 30\% microcrystalline cellulose and 2\% croscarmellose sodium to the 50\% coated pellets produced fast disintegrating tablets. Dissolution profiles of both pellets and their respective matrix tablets were comparable and conformed to the USP dissolution requirement for PPA extended-release capsules.}, address = {Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.}, author = {Mitrevej, A. and Sinchaipanid, N. and Natpoolwat, N. and Naratikornrit, N.}, citeulike-article-id = {493441}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9876528}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9876528}, issn = {0363-9045}, journal = {Drug Dev Ind Pharm}, keywords = {1977-2004, and, combinations, process}, month = {August}, number = {8}, pages = {793--796}, posted-at = {2006-02-03 12:51:21}, priority = {3}, title = {Fabrication of multiunit controlled-release phenylpropanolamine hydrochloride tablets.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9876528}, volume = {24}, year = {1998} }

TY - JOUR ID - citeulike:493441 L3 - citeulike-article-id:493441 N2 - Phenylpropanolamine hydrochloride (PPA) pellets were prepared in a fluidized-bed rotary granulator. Microcrystalline cellulose and distilled water were used as pelletization enhancer and binder, respectively. The pellets were coated with methacrylate ester copolymer (Eudragit RS 100) solution containing a 1:1 ratio mixture of triethyl citrate and castor oil as plasticizers. The addition of approximately 30% microcrystalline cellulose and 2% croscarmellose sodium to the 50% coated pellets produced fast disintegrating tablets. Dissolution profiles of both pellets and their respective matrix tablets were comparable and conformed to the USP dissolution requirement for PPA extended-release capsules. IS - 8 JF - Drug Dev Ind Pharm SN - 0363-9045 AD - Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. EP - 796 TI - Fabrication of multiunit controlled-release phenylpropanolamine hydrochloride tablets. VL - 24 SP - 793 KW - 1977-2004 KW - and KW - combinations KW - process AU - Mitrevej, A AU - Sinchaipanid, N AU - Natpoolwat, N AU - Naratikornrit, N PY - 1998/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/9876528 ER -