Kinetics of drug release from solid matrices: effect of compaction pressure Export

@article{citeulike:493484, abstract = {Measurements have been made of the compactibility of drug/polymers and their mixtures with directly compressible excipients, and of the tensile strength of the solid matrices produced either by fusion or by physical mixing. It was found that at a relatively low compaction force a plateau is observed without appreciable change in tensile strength at greater pressure. The influence of compression force on dissolution rate in both the initial release phase and the matrix-controlled diffusion phase was determined. It was shown that dissolution of a drug from insoluble and partially soluble matrices follows the Higuchi square-root equation. Release profiles of solid matrices produced from isotropic dispersions obtained by fusion are susceptible to compression force in both the initial and terminal phases with significant differences in the slopes of square-root plots. Furthermore, drug release from physical mixtures of directly compressed formulations is not affected by an increase in compression force. There is no significant change in the slopes of release profiles which have consistently higher correlation coefficients.}, author = {Fassihi, A. R.}, citeulike-article-id = {493484}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/0378-5173(87)90016-0}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T7W-4755084-1S/2/39bb35422b30af81362da9e3189d8110}, doi = {10.1016/0378-5173(87)90016-0}, journal = {International Journal of Pharmaceutics}, keywords = {1977-2004, and, combinations, process}, month = {June}, number = {1-2}, pages = {119--125}, posted-at = {2006-02-03 13:43:26}, priority = {3}, title = {Kinetics of drug release from solid matrices: effect of compaction pressure}, url = {http://dx.doi.org/10.1016/0378-5173(87)90016-0}, volume = {37}, year = {1987} }

TY - JOUR ID - citeulike:493484 L3 - citeulike-article-id:493484 N2 - Measurements have been made of the compactibility of drug/polymers and their mixtures with directly compressible excipients, and of the tensile strength of the solid matrices produced either by fusion or by physical mixing. It was found that at a relatively low compaction force a plateau is observed without appreciable change in tensile strength at greater pressure. The influence of compression force on dissolution rate in both the initial release phase and the matrix-controlled diffusion phase was determined. It was shown that dissolution of a drug from insoluble and partially soluble matrices follows the Higuchi square-root equation. Release profiles of solid matrices produced from isotropic dispersions obtained by fusion are susceptible to compression force in both the initial and terminal phases with significant differences in the slopes of square-root plots. Furthermore, drug release from physical mixtures of directly compressed formulations is not affected by an increase in compression force. There is no significant change in the slopes of release profiles which have consistently higher correlation coefficients. IS - 1-2 JF - International Journal of Pharmaceutics EP - 125 TI - Kinetics of drug release from solid matrices: effect of compaction pressure VL - 37 SP - 119 KW - 1977-2004 KW - and KW - combinations KW - process AU - Fassihi, AR PY - 1987/06// UR - http://dx.doi.org/10.1016/0378-5173(87)90016-0 ER -