Phosphatidylinositol 3-kinase Export

@article{citeulike:220870, abstract = {Currently, a central question in biology is how signals from the cell surface modulate intracellular processes. In recent years phosphoinositides have been shown to play a key role in signal transduction. Two phosphoinositide pathways have been characterized, to date. In the canonical phosphoinositide turnover pathway, activation of phosphatidylinositol-specific phospholipase C results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate and the generation of two second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. The 3-phosphoinositide pathway involves protein-tyrosine kinase-mediated recruitment and activation of phosphatidylinositol 3-kinase, resulting in the production of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. The 3-phosphoinositides are not substrates of any known phospholipase C, are not components of the canonical phosphoinositide turnover pathway, and may themselves act as intracellular mediators. The 3-phosphoinositide pathway has been implicated in growth factor-dependent mitogenesis, membrane ruffling and glucose uptake. Furthermore the homology of the yeast vps34 with the mammalian phosphatidylinositol 3-kinase has suggested a role for this pathway in vesicular trafficking. In this review the different mechanisms employed by protein-tyrosine kinases to activate phosphatidylinositol 3-kinase, and its involvement in the signaling cascade initiated by tyrosine phosphorylation, are examined.}, author = {Kapeller, R. and Cantley, L. C.}, citeulike-article-id = {220870}, journal = {BioEssays : news and reviews in molecular, cellular and developmental biology}, keywords = {1-phosphatidylinositol, 3-kinase, alcohol, amino, biological, molecular, phosphatidylinositol, phosphotransferase, protein-tyrosine, sequence, transduction}, number = {8}, pages = {565--576}, posted-at = {2005-06-06 17:47:52}, priority = {2}, title = {Phosphatidylinositol 3-kinase}, volume = {16}, year = {1994} }

TY - JOUR ID - citeulike:220870 L3 - citeulike-article-id:220870 N2 - Currently, a central question in biology is how signals from the cell surface modulate intracellular processes. In recent years phosphoinositides have been shown to play a key role in signal transduction. Two phosphoinositide pathways have been characterized, to date. In the canonical phosphoinositide turnover pathway, activation of phosphatidylinositol-specific phospholipase C results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate and the generation of two second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. The 3-phosphoinositide pathway involves protein-tyrosine kinase-mediated recruitment and activation of phosphatidylinositol 3-kinase, resulting in the production of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. The 3-phosphoinositides are not substrates of any known phospholipase C, are not components of the canonical phosphoinositide turnover pathway, and may themselves act as intracellular mediators. The 3-phosphoinositide pathway has been implicated in growth factor-dependent mitogenesis, membrane ruffling and glucose uptake. Furthermore the homology of the yeast vps34 with the mammalian phosphatidylinositol 3-kinase has suggested a role for this pathway in vesicular trafficking. In this review the different mechanisms employed by protein-tyrosine kinases to activate phosphatidylinositol 3-kinase, and its involvement in the signaling cascade initiated by tyrosine phosphorylation, are examined. IS - 8 JF - BioEssays : news and reviews in molecular, cellular and developmental biology EP - 576 TI - Phosphatidylinositol 3-kinase VL - 16 SP - 565 KW - 1-phosphatidylinositol KW - 3-kinase KW - alcohol KW - amino KW - biological KW - molecular KW - phosphatidylinositol KW - phosphotransferase KW - protein-tyrosine KW - sequence KW - transduction AU - Kapeller, R AU - Cantley, LC PY - 1994/// ER -