Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate Export

@article{citeulike:2842496, abstract = {Metabolically-stabilized analogs of PtdIns(3,4,5)P3 have shown long-lived agonist activity for cellular events mediated by this phosphoinositide. We describe an efficient method for the total asymmetric synthesis of the trisphosphorothioate (PT) analog of PtdIns(3,4,5)P3. Intracellular delivery of dipalmitoyl PtdIns(3,4,5)PT3-mimicked insulin in activating sodium transport in A6 cells.}, author = {Zhang, Honglu and Xu, Yong and Markadieu, Nicolas and Beauwens, Renaud and Erneux, Christophe and Prestwich, Glenn D.}, citeulike-article-id = {2842496}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bmcl.2007.11.041}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6TF9-4R53SVM-5/1/0821160983cc18280c2788d6f3d2ca0d}, day = {15}, doi = {10.1016/j.bmcl.2007.11.041}, journal = {Bioorganic \& Medicinal Chemistry Letters}, keywords = {phosphoinositides, pip2, pip3, synthesis}, month = {January}, number = {2}, pages = {762--766}, posted-at = {2008-05-28 19:34:13}, priority = {2}, title = {Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate}, url = {http://dx.doi.org/10.1016/j.bmcl.2007.11.041}, volume = {18}, year = {2008} }

TY - JOUR ID - citeulike:2842496 L3 - citeulike-article-id:2842496 N2 - Metabolically-stabilized analogs of PtdIns(3,4,5)P3 have shown long-lived agonist activity for cellular events mediated by this phosphoinositide. We describe an efficient method for the total asymmetric synthesis of the trisphosphorothioate (PT) analog of PtdIns(3,4,5)P3. Intracellular delivery of dipalmitoyl PtdIns(3,4,5)PT3-mimicked insulin in activating sodium transport in A6 cells. IS - 2 JF - Bioorganic & Medicinal Chemistry Letters EP - 766 TI - Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate VL - 18 SP - 762 KW - phosphoinositides KW - pip2 KW - pip3 KW - synthesis AU - Zhang, Honglu AU - Xu, Yong AU - Markadieu, Nicolas AU - Beauwens, Renaud AU - Erneux, Christophe AU - Prestwich, Glenn PY - 2008/01/15/ UR - http://dx.doi.org/10.1016/j.bmcl.2007.11.041 ER -