PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why? Export

@article{citeulike:5845904, abstract = {Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity.}, author = {Suh, Byung C. and Hille, Bertil}, citeulike-article-id = {5845904}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.biophys.37.032807.125859}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.biophys.37.032807.125859}, doi = {10.1146/annurev.biophys.37.032807.125859}, journal = {Annual Review of Biophysics}, keywords = {activation, channel, kir, pip2, review}, number = {1}, pages = {175--195}, posted-at = {2009-09-27 23:14:16}, priority = {2}, title = {PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?}, url = {http://dx.doi.org/10.1146/annurev.biophys.37.032807.125859}, volume = {37}, year = {2008} }

TY - JOUR ID - citeulike:5845904 L3 - citeulike-article-id:5845904 N2 - Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity. IS - 1 JF - Annual Review of Biophysics EP - 195 TI - PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why? VL - 37 SP - 175 KW - activation KW - channel KW - kir KW - pip2 KW - review AU - Suh, Byung AU - Hille, Bertil PY - 2008/// UR - http://dx.doi.org/10.1146/annurev.biophys.37.032807.125859 ER -