Acetylcholine receptor channel imaged in the open state. Export

@article{citeulike:5969075, abstract = {The structure of the open-channel form of the acetylcholine receptor has been determined from electron images of Torpedo ray postsynaptic membranes activated by brief (< 5 ms) mixing with droplets containing acetylcholine. Comparison with the closed-channel form shows that acetylcholine initiates small rotations of the subunits in the extracellular domain, which trigger a change in configuration of alpha-helices lining the membrane-spanning pore. The open pore tapers towards the intracellular membrane face, where it is shaped by a 'barrel' of alpha-helices having a pronounced right-handed twist.}, author = {Unwin, N.}, citeulike-article-id = {5969075}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/373037a0}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/7800037}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=7800037}, day = {5}, doi = {10.1038/373037a0}, issn = {0028-0836}, journal = {Nature}, keywords = {ach, ach-receptor-channel}, month = {January}, number = {6509}, pages = {37--43}, posted-at = {2009-10-19 06:25:22}, priority = {2}, title = {Acetylcholine receptor channel imaged in the open state.}, url = {http://dx.doi.org/10.1038/373037a0}, volume = {373}, year = {1995} }

TY - JOUR ID - citeulike:5969075 L3 - citeulike-article-id:5969075 N2 - The structure of the open-channel form of the acetylcholine receptor has been determined from electron images of Torpedo ray postsynaptic membranes activated by brief (< 5 ms) mixing with droplets containing acetylcholine. Comparison with the closed-channel form shows that acetylcholine initiates small rotations of the subunits in the extracellular domain, which trigger a change in configuration of alpha-helices lining the membrane-spanning pore. The open pore tapers towards the intracellular membrane face, where it is shaped by a 'barrel' of alpha-helices having a pronounced right-handed twist. IS - 6509 JF - Nature SN - 0028-0836 EP - 43 TI - Acetylcholine receptor channel imaged in the open state. VL - 373 SP - 37 KW - ach KW - ach-receptor-channel AU - Unwin, N PY - 1995/01/05/ UR - http://dx.doi.org/10.1038/373037a0 ER -