Cys-loop receptors: new twists and turns. Export

@article{citeulike:6055017, abstract = {New hypotheses and predictions have arisen from recent work revealing atomic-scale or near-atomic-scale structures of receptors in the 'Cys-loop' superfamily. How general is the cation-pi interaction between the natural ligand and a tryptophan residue in the aromatic box, and does this interaction extend to other ligands? What is the pathway from the binding site to gating, and what are the conformational changes during gating and desensitization? Is current flow through intracellular 'portals' in the wall of the channel a general feature? This article discusses these and related questions, emphasizing nicotinic ACh receptors and also discussing data from other members of this superfamily.}, author = {Lester, Henry A. and Dibas, Mohammed I. and Dahan, David S. and Leite, John F. and Dougherty, Dennis A.}, citeulike-article-id = {6055017}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tins.2004.04.002}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15165737}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15165737}, doi = {10.1016/j.tins.2004.04.002}, issn = {0166-2236}, journal = {Trends in neurosciences}, keywords = {ach-receptor-channel, gating}, month = {June}, number = {6}, pages = {329--336}, posted-at = {2009-11-02 02:43:34}, priority = {2}, title = {Cys-loop receptors: new twists and turns.}, url = {http://dx.doi.org/10.1016/j.tins.2004.04.002}, volume = {27}, year = {2004} }

TY - JOUR ID - citeulike:6055017 L3 - citeulike-article-id:6055017 N2 - New hypotheses and predictions have arisen from recent work revealing atomic-scale or near-atomic-scale structures of receptors in the 'Cys-loop' superfamily. How general is the cation-pi interaction between the natural ligand and a tryptophan residue in the aromatic box, and does this interaction extend to other ligands? What is the pathway from the binding site to gating, and what are the conformational changes during gating and desensitization? Is current flow through intracellular 'portals' in the wall of the channel a general feature? This article discusses these and related questions, emphasizing nicotinic ACh receptors and also discussing data from other members of this superfamily. IS - 6 JF - Trends in neurosciences SN - 0166-2236 EP - 336 TI - Cys-loop receptors: new twists and turns. VL - 27 SP - 329 KW - ach-receptor-channel KW - gating AU - Lester, Henry AU - Dibas, Mohammed AU - Dahan, David AU - Leite, John AU - Dougherty, Dennis PY - 2004/06// UR - http://dx.doi.org/10.1016/j.tins.2004.04.002 ER -