A Macaque's-Eye View of Human Insertions and Deletions: Differences in Mechanisms Export

@article{citeulike:1660975, abstract = {Author SummaryInsertions and deletions (indels) represent a significant source of evolutionary change. In this manuscript, the authors investigate the patterns of genome-wide rate variation for indels that occurred in the human lineage since its divergence from chimpanzee. Earlier work suggested that insertion and deletion rates are correlated, implying that some genomic factors might affect both types of mutations and thus their patterns of variation across the genome. However, sequences evolving under and without selection were considered together. The present study represents the first attempt to quantify the levels of variation in neutral indel rates in the framework of multiple regression analysis. The finding that insertion versus deletion rates correlate with different genomic features suggests that these two types of mutation are caused in part by distinct molecular mechanisms. This conclusion has direct implications for understanding human genetic diseases, since a large number of them are caused by indels, and contributes to the growing recognition of the importance of fine-scale rearrangement in shaping genome evolution.}, author = {Kvikstad, Erika M. and Tyekucheva, Svitlana and Chiaromonte, Francesca and Makova, Kateryna D.}, citeulike-article-id = {1660975}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pcbi.0030176}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17941704}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17941704}, day = {14}, doi = {10.1371/journal.pcbi.0030176}, journal = {PLoS Comput Biol}, keywords = {evolution, indel, primates}, month = {September}, number = {9}, pages = {e176+}, posted-at = {2007-09-15 17:00:03}, priority = {2}, publisher = {Public Library of Science}, title = {A Macaque's-Eye View of Human Insertions and Deletions: Differences in Mechanisms}, url = {http://dx.doi.org/10.1371/journal.pcbi.0030176}, volume = {3}, year = {2007} }

TY - JOUR ID - citeulike:1660975 L3 - citeulike-article-id:1660975 N2 - Author SummaryInsertions and deletions (indels) represent a significant source of evolutionary change. In this manuscript, the authors investigate the patterns of genome-wide rate variation for indels that occurred in the human lineage since its divergence from chimpanzee. Earlier work suggested that insertion and deletion rates are correlated, implying that some genomic factors might affect both types of mutations and thus their patterns of variation across the genome. However, sequences evolving under and without selection were considered together. The present study represents the first attempt to quantify the levels of variation in neutral indel rates in the framework of multiple regression analysis. The finding that insertion versus deletion rates correlate with different genomic features suggests that these two types of mutation are caused in part by distinct molecular mechanisms. This conclusion has direct implications for understanding human genetic diseases, since a large number of them are caused by indels, and contributes to the growing recognition of the importance of fine-scale rearrangement in shaping genome evolution. IS - 9 JF - PLoS Comput Biol TI - A Macaque's-Eye View of Human Insertions and Deletions: Differences in Mechanisms PB - Public Library of Science VL - 3 SP - e176 KW - evolution KW - indel KW - primates AU - Kvikstad, Erika AU - Tyekucheva, Svitlana AU - Chiaromonte, Francesca AU - Makova, Kateryna PY - 2007/09/14/ UR - http://dx.doi.org/10.1371/journal.pcbi.0030176 ER -