Quantifying the Stationarity and Time Reversibility of the Nucleotide Substitution Process Export

@article{citeulike:3125303, abstract = {Markov models describing the evolution of the nucleotide substitution process, widely used in phylogeny reconstruction, usually assume the hypotheses of stationarity and time reversibility. Although these models give meaningful results when applied to biological data, it is not clear if the two assumptions mentioned above hold and, if not, how much sequence evolution processes deviate from them. To this aim we introduce two sets of indices which can be calculated from the nucleotide distribution and the substitution rates. The stationarity indices (STIs) can be used to test the validity of the equilibrium assumption. The irreversibility indices (IRIs) are derived from the Kolmogorov cycle conditions for time reversibility and quantify the degree of non time reversibility of a process. We have computed STIs and IRIs for the evolutionary process of two lineages, Drosophila simulans and Homo sapiens. In the latter case we use a modified form of the indices which takes into account the CpG decay process. In both cases we find statistically significant deviations from the ideal case of a process which has reached stationarity and is time reversible. 10.1093/molbev/msn169}, author = {Squartini, Federico and Arndt, Peter F.}, citeulike-article-id = {3125303}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/molbev/msn169}, citeulike-linkout-1 = {http://mbe.oxfordjournals.org/cgi/content/abstract/25/12/2525}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18682605}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18682605}, day = {14}, doi = {10.1093/molbev/msn169}, journal = {Mol Biol Evol}, keywords = {evolution, model\_selection}, month = {August}, pages = {msn169+}, posted-at = {2008-11-14 22:43:01}, priority = {2}, title = {Quantifying the Stationarity and Time Reversibility of the Nucleotide Substitution Process}, url = {http://dx.doi.org/10.1093/molbev/msn169}, year = {2008} }

TY - JOUR ID - citeulike:3125303 L3 - citeulike-article-id:3125303 N2 - Markov models describing the evolution of the nucleotide substitution process, widely used in phylogeny reconstruction, usually assume the hypotheses of stationarity and time reversibility. Although these models give meaningful results when applied to biological data, it is not clear if the two assumptions mentioned above hold and, if not, how much sequence evolution processes deviate from them. To this aim we introduce two sets of indices which can be calculated from the nucleotide distribution and the substitution rates. The stationarity indices (STIs) can be used to test the validity of the equilibrium assumption. The irreversibility indices (IRIs) are derived from the Kolmogorov cycle conditions for time reversibility and quantify the degree of non time reversibility of a process. We have computed STIs and IRIs for the evolutionary process of two lineages, Drosophila simulans and Homo sapiens. In the latter case we use a modified form of the indices which takes into account the CpG decay process. In both cases we find statistically significant deviations from the ideal case of a process which has reached stationarity and is time reversible. 10.1093/molbev/msn169 JF - Mol Biol Evol TI - Quantifying the Stationarity and Time Reversibility of the Nucleotide Substitution Process SP - msn169 KW - evolution KW - model_selection AU - Squartini, Federico AU - Arndt, Peter PY - 2008/08/14/ UR - http://dx.doi.org/10.1093/molbev/msn169 ER -