Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis Export

@article{citeulike:4684919, abstract = {Our understanding of the evolution, formation, and pathological disruption of human brain circuits is impeded by a lack of comprehensive data on the developing brain transcriptome. A whole-genome, exon-level expression analysis of 13 regions from left and right sides of the mid-fetal human brain revealed that 76\% of genes are expressed, and 44\% of these are differentially regulated. These data reveal a large number of specific gene expression and alternative splicing patterns, as well as coexpression networks, associated with distinct regions and neurodevelopmental processes. Of particular relevance to cognitive specializations, we have characterized the transcriptional landscapes of prefrontal cortex and perisylvian speech and language areas, which exhibit a population-level global expression symmetry. We show that differentially expressed genes are more frequently associated with human-specific evolution of putative cis-regulatory elements. These data provide a wealth of biological insights into the complex transcriptional and molecular underpinnings of human brain development and evolution.}, author = {Johnson, Matthew B. and Kawasawa, Yuka I. and Mason, Christopher E. and Krsnik, \v{Z}eljka and Coppola, Giovanni and Bogdanovi\'{c}, Darko and Geschwind, Daniel H. and Mane, Shrikant M. and State, Matthew W. and \v{S}estan, Nenad}, citeulike-article-id = {4684919}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2009.03.027}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0896627309002864}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19477152}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19477152}, day = {28}, doi = {10.1016/j.neuron.2009.03.027}, issn = {08966273}, journal = {Neuron}, keywords = {brain, development, expression, human, tf}, month = {May}, number = {4}, pages = {494--509}, posted-at = {2009-11-04 21:10:24}, priority = {2}, title = {Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis}, url = {http://dx.doi.org/10.1016/j.neuron.2009.03.027}, volume = {62}, year = {2009} }

TY - JOUR ID - citeulike:4684919 L3 - citeulike-article-id:4684919 N2 - Our understanding of the evolution, formation, and pathological disruption of human brain circuits is impeded by a lack of comprehensive data on the developing brain transcriptome. A whole-genome, exon-level expression analysis of 13 regions from left and right sides of the mid-fetal human brain revealed that 76% of genes are expressed, and 44% of these are differentially regulated. These data reveal a large number of specific gene expression and alternative splicing patterns, as well as coexpression networks, associated with distinct regions and neurodevelopmental processes. Of particular relevance to cognitive specializations, we have characterized the transcriptional landscapes of prefrontal cortex and perisylvian speech and language areas, which exhibit a population-level global expression symmetry. We show that differentially expressed genes are more frequently associated with human-specific evolution of putative cis-regulatory elements. These data provide a wealth of biological insights into the complex transcriptional and molecular underpinnings of human brain development and evolution. IS - 4 JF - Neuron SN - 08966273 EP - 509 TI - Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis VL - 62 SP - 494 KW - brain KW - development KW - expression KW - human KW - tf AU - Johnson, Matthew AU - Kawasawa, Yuka AU - Mason, Christopher AU - Krsnik, Željka AU - Coppola, Giovanni AU - Bogdanović, Darko AU - Geschwind, Daniel AU - Mane, Shrikant AU - State, Matthew AU - Šestan, Nenad PY - 2009/05/28/ UR - http://dx.doi.org/10.1016/j.neuron.2009.03.027 ER -